Evidence map›Paper›PMID 39563668›Full record

ArticleCytoJournal2024

Newcastle disease virus promotes pyroptosis in medulloblastoma cells by regulating interferon-gamma-mediated guanylate-binding protein 1 expression and activating caspase-4.

Pengwu Ren, Jiayan Yu, Dongxiang Wang, Lijuan Zeng, Xianqiang Zhang, Xiaohe Liu, Yongfu Cao, Zijian Hu, Xiaoyong Zhao, Kongbin Yang

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Article in CytoJournal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Pengwu RenDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.
Jiayan YuDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.
Dongxiang WangDepartment of Dermatology, The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
Lijuan ZengDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.
Xianqiang ZhangDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.
Xiaohe LiuDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.
Yongfu CaoDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.
Zijian HuDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.
Xiaoyong ZhaoDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.
Kongbin YangDepartment of Neurosurgery, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The literature has reported that Newcastle disease virus (NDV) can have inhibitory effects on various tumors. This study aims to investigate the mechanism by which NDV induces pyroptosis in medulloblastoma (MB) cells. Material and Methods: We treated MB cell lines Daoy and D283 with NDV or recombinant interferon-gamma (IFN-g) proteins. Guanylate-binding proteins (GBPs) were measured using real-time quantitative polymerase chain reaction. Small interfering RNA-specific targeting Results: Bioinformatics analysis revealed that GBP family genes and interferon-related genes might be responsive to NDV stimulation in MB cells. Treatment with NDV resulted in increased IFN-g levels and upregulated GBP expression, particularly Conclusion: Our findings suggest that NDV elevates IFN-g and

Indexed as

Caspase-4Interferon-gammaNewcastle disease virus (NDV)Pyroptosis

Identifiers

PMID39563668
PMCPMC11574683

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.