Evidence map›Paper›PMID 39563575›Full record

ArticleChemistry & biodiversity2025

Solid State Synthesis of Hyaluronic Acid-Quercetin Conjugate: Sustainable Protocol to Improve the Biological Activity of Quercetin.

Valentina Verdoliva, Giuliana Muzio, Riccardo Autelli, Stefania De Luca

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Valentina VerdolivaInstitute of Crystallography, National Research Council, Caserta, Italy.
Giuliana MuzioDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Riccardo AutelliDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Stefania De LucaInstitute of Biostructures and Bioimaging, National Research Council, Naples, Italy.ORCID https://orcid.org/0000-0002-7078-1696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, a sustainable solid-state procedure is employed for the synthesis of a water-soluble molecule obtained by linking hyaluronic acid to the hydrophobic quercetin (HA-QCT). The micellar self-aggregation of the developed conjugate suggested its employment as a drug delivery nano-system, considering the numerous biological activities of QCT. Indeed, the spectroscopic characterization (ultraviolet-visible and Fourier transform infrared) ensured that the QCT maintained its chemical integrity. In addition, a cytotoxicity test revealed that HA-QCT can be employed as a biocompatible drug vehicle for pharmacological purposes. A preliminary colorimetric test also confirmed that QCT retained its anti-oxidant activity.

Indexed as

AntioxidantsHyaluronic AcidQuercetinCell SurvivalHumansHydrophobic and Hydrophilic InteractionsMicellesMolecular StructureAntioxidantsHyaluronic AcidMicellesQuercetinanti‐oxidant activity of quercetinhyaluronan−quercetin conjugatenano‐carrier of quercetinpharmacological activity of quercetinsolvent‐free protocol

Identifiers

PMID39563575
PMCPMC12004894

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.