ArticleStem cell research & therapy2024
Subretinal microglia support donor photoreceptor survival in rd1 mice.
Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Applications of Modern Cell Therapies: The Latest Data in Ophthalmology.Life (Basel, Switzerland) · 2025Review
- The neuroimmune interface in retinal regeneration.Progress in retinal and eye research · 2025Review
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Authors and funding
5 authors.
Funding
Abstract
purposeTo investigate the potential relationship between subretinal microglia and transplanted donor photoreceptors.
methodsPhotoreceptor precursors were transplanted into wild-type mice and rd1 mice by trans-scleral injection. Immunohistochemistry was employed to detect microglia and macrophages. PlX5622 feed was used to achieve microglia depletion and microglia repopulation. RNA-seq and qPCR were utilized to evaluate gene expression. Confocal microscopy was used to observe the interaction between microglia and donor photoreceptors.
resultsDonor photoreceptors survived in rd1 mice but not in wild-type mice after trans-scleral injection. The microglial cells closely interacted with donor cells. While donor cells failed to survive in rd1 mice after microglia depletion, they could survive following microglia repopulation. The RNA-seq analysis showed a pro-neurodevelopmental effect of sub-retinal microglia/RPE tissue in rd1 mice.
conclusionsSubretinal microglia supported donor photoreceptor survival in rd1 mice.
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