Evidence map›Paper›PMID 39563399›Full record

ArticleBMC oral health2024

Automated pipeline for linear and volumetric assessment of facial swelling after third molar surgery.

Selene Barone, Paolo Zaffino, Marianna Salviati, Michela Destito, Alessandro Antonelli, Francesco Bennardo, Lucia Cevidanes, Maria Francesca Spadea, Amerigo Giudice

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07368114 (Validity of Ozonated Olive Oil Gel Versus Injectable Bone Graft on Osseointegration of Immediate Dental Implants), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07368114 phase2completednot on this map

Validity of Ozonated Olive Oil Gel Versus Injectable Bone Graft on Osseointegration of Immediate Dental Implants

TypeinterventionalSponsorSuez Canal UniversityRan2023 to 2025Enrolled16ConditionsDental, Implant Osseointegration, Ozone Therapy, Bone GraftArmsImmediate implant placement, β-tricalcium phosphate Injectable Bone Graft, Ozonated olive oil gel
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Selene BaroneSchool of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Viale Europa, Catanzaro, 88100, Italy. selene.barone@unicz.it.ORCID https://orcid.org/0000-0002-0701-2675
Paolo ZaffinoDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Viale Europa, Catanzaro, 88100, Italy.ORCID https://orcid.org/0000-0002-0219-0157
Marianna SalviatiSchool of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Viale Europa, Catanzaro, 88100, Italy.ORCID https://orcid.org/0000-0002-8913-6371
Michela DestitoDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Viale Europa, Catanzaro, 88100, Italy.ORCID https://orcid.org/0000-0002-1720-3029
Alessandro AntonelliSchool of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Viale Europa, Catanzaro, 88100, Italy.ORCID https://orcid.org/0000-0002-9557-3586
Francesco BennardoSchool of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Viale Europa, Catanzaro, 88100, Italy.ORCID https://orcid.org/0000-0002-6528-2681
Lucia CevidanesSchool of Dentistry, Department of Orthodontics and Pediatric Dentistry, University of Michigan, Ann Arbor, USA.ORCID https://orcid.org/0000-0001-9786-2253
Maria Francesca SpadeaInstitute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-5339-9583
Amerigo GiudiceSchool of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Viale Europa, Catanzaro, 88100, Italy.ORCID https://orcid.org/0000-0002-5091-6979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtraction of mandibular third molars (M3Ms) is a routine procedure in oral and maxillofacial surgery, often associated with postoperative symptoms like pain, facial swelling, and trismus. This study aimed to introduce a standardized and automated protocol for swelling analysis following M3M surgery, presenting results regarding clinical conditions immediately and one-week after surgery.

methodsIn a prospective study, 35 patients were enrolled (mean age: 24.4 ± 5.8 years) for removal of 54 M3Ms. Facial swelling was evaluated through 3D facial scans before surgery (T0), at three days (T1), and seven days (T2) post-surgery. The open-source software 3DSlicer facilitated automated analysis, including data anonymization, orientation, surface registration, qualitative comparisons, linear measurements, and volumetric quantification. Pairwise superimposition of facial models enabled qualitative, vectorial, and quantitative assessments, comparing initial conditions with swelling development at T1 and T2. Additionally, changes between T1 and T2 were also evaluated. Secondary outcomes encompassed clinical evaluations of pain, trismus (maximum mouth opening), and surgery time. Statistical analysis involved the paired Student t-test to assess longitudinal changes and analysis of variance to evaluate outcome variables concerning difficulty scores. Linear regression models correlated primary outcome variables with secondary study variables (α < 0.05).

resultsLongitudinal analysis demonstrated significant but variable facial swelling, pain, and trismus at T1, followed by improvement at T2 (p < 0.001). Linear and volumetric differences correlated positively with surgery time (p < 0.05). A direct proportionality between linear and volume differences was observed, higher values at T1 correlated with higher values at T2 (p < 0.05).

conclusionsAn innovative digital workflow for precise quantification of postoperative facial changes was implemented, incorporating volumetric measurements that surpass linear assessments. Clinical conditions demonstrated a direct correlation with surgery time, deteriorating immediately and improving one-week after surgery.

Indexed as

EdemaFaceImaging, Three-DimensionalMolar, ThirdTooth ExtractionAdultFemaleHumansMaleMandiblePostoperative ComplicationsPostoperative PainProspective StudiesTrismusYoung Adult3D swelling analysisFacial scannerThird molar surgery edemaThree-dimensional surface imagingVolumetric measurements

Identifiers

PMID39563399
PMCPMC11575084

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.