Evidence map›Paper›PMID 39563380›Full record

ArticleJournal of nanobiotechnology2024

Microenvironment-optimized gastrodin-functionalized scaffolds orchestrate asymmetric division of recruited stem cells in endogenous bone regeneration.

Shilin Pan, Yao Li, Lu Wang, Yingchao Guan, Kaiyang Xv, Qing Li, Guangli Feng, Yingrui Hu, Xiaoqian Lan, Shiyi Qin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shilin Pan *Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical University, Kunming, 650500, China.
Yao Li *Department of Stomatology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
Lu WangYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical University, Kunming, 650500, China.
Yingchao GuanYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical University, Kunming, 650500, China.
Kaiyang XvYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical University, Kunming, 650500, China.
Qing LiYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical University, Kunming, 650500, China.
Guangli FengDepartment of Neurology, The First Affiliated Hospital, Kunming Medical University, Kunming, 650032, China.
Yingrui HuYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical University, Kunming, 650500, China.
Xiaoqian LanDepartment of Neurology, The First Affiliated Hospital, Kunming Medical University, Kunming, 650032, China.
Shiyi QinDepartment of Neurology, The First Affiliated Hospital, Kunming Medical University, Kunming, 650032, China.
Li GuiDepartment of Endocrinology, The Third People's Hospital of Yunnan Province, Kunming, 650011, China. guili0527@126.com.
Limei LiYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical University, Kunming, 650500, China. scullm@163.com.

Funding

National Natural Science Foundation of China 82160175National Natural Science Foundation of China 82260366Yunnan Science and Technology Program 202201AT070136Yunnan Science and Tehcnology Program 202301AY070001-032
6 · The paper itself

Abstract

The regeneration of osteoporotic bone defects remains challenging as the critical stem cell function is impaired by inflammatory microenvironment. Synthetic materials that intrinsically direct osteo-differentiation versus self-renewal of recruited stem cell represent a promising alternative strategy for endogenous bone formation. Therefore, a microenvironmentally optimized polyurethane (PU) /n-HA scaffold to enable sustained delivery of gastrodin is engineered to study its effect on the osteogenic fate of stem cells. It exhibited interconnected porous networks and an elevated sequential gastrodin release pattern to match immune-osteo cascade concurrent with progressive degradation of materials. In a critical-sized femur defect model of osteoporotic rat, 5% gastrodin-PU/n-HA potently promoted neo-bone regeneration by facilitating M2 macrophage polarization and CD146

Indexed as

Benzyl AlcoholsBone RegenerationGlucosidesMesenchymal Stem CellsOsteogenesisRats, Sprague-DawleyTissue ScaffoldsAnimalsAsymmetric Cell DivisionCell DifferentiationCell ProliferationCells, CulturedCellular MicroenvironmentFemaleOsteoporosisRatsBenzyl AlcoholsgastrodinGlucosidesAsymmetric cell divisionEndogenous bone regenerationGastrodin deliveryMicroenvironment regulationOsteogenic differentiation

Identifiers

PMID39563380
PMCPMC11577785

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.