Evidence map›Paper›PMID 39563349›Full record

ArticleBMC complementary medicine and therapies2024

The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel.

Cynthia J Henley-Smith, Anna-Mari Kok, Francien S Botha, Chantelle Baker, Namrita Lall

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Article in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cynthia J Henley-SmithDepartment of Plant and Soil Science, Faculty of Natural and Agriculture Sciences, University of Pretoria, Pretoria, 0002, South Africa.
Anna-Mari KokDepartment of Plant and Soil Science, Faculty of Natural and Agriculture Sciences, University of Pretoria, Pretoria, 0002, South Africa.
Francien S BothaElectron Microscope Unit, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Chantelle BakerElectron Microscope Unit, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Namrita LallDepartment of Plant and Soil Science, Faculty of Natural and Agriculture Sciences, University of Pretoria, Pretoria, 0002, South Africa. namrita.lall@up.ac.za.

Funding

Gen foundation Grant NANational Research Foundation 90355
6 · The paper itself

Abstract

backgroundDental caries, also known as tooth decay or cavity formation, is one of the world's most widespread dental conditions. It is a plaque-related infection caused mainly by Streptococcus mutans. People have relied on several plant species to treat oral infections; Heteropyxis natalensis, for example, has been used to treat toothache and gum infections.

methodsIn this study, the antimicrobial and anti-adherence properties of H. natalensis and Camellia sinensis, as well as tea tree and peppermint essential oils were investigated on tooth enamel.

resultsThe bacterial load of S. mutans was reduced by approximately two orders of a magnitude after 48 h, with a lesser extent on the commensal bacteria, Lactobacillus paracasei. Scanning electron micrographs of enamel blocks showed a reduction in the attachment and chain formation of S. mutans and degraded cell morphology. Lastly, the combination and each component individually, showed low to no cellular toxicity when tested on human macrophages.

conclusionsThis is the first report of this polyherbal regarding its selectivity and potential prevention of dental caries.

Indexed as

Bacterial AdhesionDental EnamelPlant ExtractsStreptococcus mutansAnti-Bacterial AgentsCamellia sinensisDental CariesHumansMentha piperitaOils, VolatileAnti-Bacterial AgentsOils, VolatilePlant ExtractsAnti-adherenceCariesHeteropyxis natalensisLactobacillus paracaseiOral cavityStreptococcus mutans

Identifiers

PMID39563349
PMCPMC11575210

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.