ArticleCardiovascular diabetology2024
Different associations of atherogenic index of plasma, triglyceride glucose index, and hemoglobin A1C levels with the risk of coronary artery calcification progression according to established diabetes.
Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Synergistic effects of insulin resistance and revascularization completeness on prognosis in patients with coronary artery calcification.Cardiovascular diabetology · 2026Observational
- Triglyceride glucose index and smoking are linked to new coronary artery calcification after normal baseline scan.Scientific reports · 2026Article
- Article
- Association between atherosclerotic index of plasma and long-term aortic-related adverse events in type B aortic dissection patients undergoing thoracic endovascular aortic repair.Cardiovascular diabetology · 2026Article
- The serum ANGPTL4 level and severe coronary artery calcification: from association to risk prediction using a nomogram.Frontiers in cardiovascular medicine · 2026Article
- Correlation of triglyceride glucose-body mass index, bedside index for severity in acute pancreatitis, and C-reactive protein-to-lymphocyte ratio with disease severity in patients with hyperlipidemic acute pancreatitis: A retrospective-cohort study.The Journal of international medical research · 2026Article
- Association between the atherogenic index of plasma and prehypertension or hypertension among adults in Fujian, China: a population-based cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Association of serum uric acid with incident vascular calcification in patients with type 2 diabetes mellitus: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- C-reactive protein-triglyceride glucose index in predicting three-vessel coronary artery disease risk: a retrospective study using machine learning approaches.Annals of medicine · 2025Article
- First-trimester atherogenic index of plasma and triglyceride-glucose indices in pregestational diabetes mellitus: associations with adverse pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Data-driven analysis of the relationship between the HbA1c/HDL-C ratio and coronary artery calcification: a cross-sectional study.Scientific reports · 2025Article
- The predictive value of atherogenic index of plasma and clonal hematopoiesis of indeterminate potential among patients with STEMI-from a prospective cohort study.Cardiovascular diabetology · 2025Article
- Association between the Triglyceride-Glucose Index and Cardiovascular Risk and Mortality across Different Diabetes Durations: A Nationwide Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Association between the atherogenic index of plasma and incident hypertension across different blood pressure states: a national cohort study.Cardiovascular diabetology · 2025Article
- The impact of glycated hemoglobin trajectories on hypertension risk: a retrospective cohort study.Frontiers in nutrition · 2025Article
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7 authors.
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Abstract
backgroundBoth insulin resistance and hyperglycemia are important risk factors for atherosclerosis. While the characteristics of atherosclerosis are obviously different according to established diabetes, little has been known regarding the risk of coronary artery calcification (CAC) progression related to the biomarkers of atherogenic index of plasma (AIP), triglyceride glucose (TyG) index, and hemoglobin A1C (HbA1C) in conditions with and without diabetes.
methodsWe analyzed 12,326 asymptomatic Korean adults (mean age 51.7 ± 8.5 years; 84.2% males; 15.8% with diabetes) over a median follow-up period of 3.0 years. AIP was defined as the base-10 logarithm of the ratio of triglyceride concentration (mmol/L) to high-density lipoprotein cholesterol (mmol/L). The TyG index was calculated as ln (fasting triglycerides [mg/dL] × fasting glucose [mg/ dL]/2). CAC progression was defined using the SQRT method, as a difference of ≥ 2.5 between the square roots (√) of baseline and follow-up coronary artery calcium scores (CACS) (Δ√transformed CACS). Logistic regression models adjusted for interscan periods were used to estimate the odds ratio (OR).
resultsThe levels of AIP, TyG index, and HbA1C were significantly higher in diabetics than in non-diabetics. CAC progression was more frequently observed in diabetics (46.9%) than in non-diabetics (28.0%). After adjusting for age, sex, hypertension, hyperlipidemia, obesity, current smoking status, serum creatinine levels, baseline CACS, and interscan period, AIP (per-0.1 unit increase) was associated with CAC progression in only non-diabetics (OR: 1.04, 95% confidence interval [CI]: 1.02 - 1.06; P < 0.001). In contrast, HbA1C level (per-1% increase) was significantly associated with CAC progression in only diabetics (OR: 1.19, 95% CI: 1.08 - 1.32; P = 0.001). The TyG index (per-1 unit increase) was associated with CAC progression in both non-diabetics (OR: 1.32, 95% CI: 1.19 - 1.46; P < 0.001) and diabetics (OR: 1.33, 95% CI: 1.10 - 1.60; P = 0.003).
conclusionsThe associations between AIP, TyG index, and HbA1C levels with CAC progression vary according to established diabetes. Of these biomarkers, TyG index is independently associated with CAC progression irrespective of established diabetes.
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