Evidence map›Paper›PMID 39563313›Full record

ArticleBMC oral health2024

Periodontitis and dental quality of life predict long-term survival in head and neck cancer.

Mirna Farran, Evelyn Neppelberg, Sigbjørn Løes, Anne K H Aarstad, Svein Erik Moe, Hans Jørgen Aarstad

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Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mirna FarranDepartment of Oral and Maxillofacial Surgery, Haukeland University Hospital, Bergen, Norway.
Evelyn NeppelbergDepartment of Oral and Maxillofacial Surgery, Haukeland University Hospital, Bergen, Norway.
Sigbjørn LøesDepartment of Oral and Maxillofacial Surgery, Haukeland University Hospital, Bergen, Norway.
Anne K H AarstadDepartment of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Bergen, 5021, Norway.
Svein Erik MoeDepartment of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Bergen, 5021, Norway.
Hans Jørgen AarstadDepartment of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Bergen, 5021, Norway. hans.jorgen.aarstad@uib.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur aim was to investigate oral health in newly diagnosed head and neck squamous cell carcinoma (HNSCC) patients in relation to long-term survival. We assessed whether the level of alveolar bone loss due to periodontitis at diagnosis, measured from orthopantomogram (OPG), and reported dental health-related quality of life (HRQoL) scores obtained at diagnosis contain prognostic information for HNSCC patients.

methodsA total of 79 patients from a consecutive cohort of 106 diagnosed with HNSCC between November 2002 and June 2005 were included. All patients reported dental HRQoL, OPG-determined alveolar bone loss were measured in 79 patients at diagnosis. Reduced alveolar bone loss (≥ 4 mm) from cement-enamel junction on at least two molars or premolars registered both horizontally and vertically served as indicator of periodontal disease.

resultsWith alveolar bone loss, we determined increased mortality by univariate analysis (RR = 2.28, CI: 1.22-4.28, p = 0.01) and a strong trend by multivariate analyses adjusted for standard clinical information (RR = 1.95, CI: 0.98-3.87, p = 0.056). Reported lowered dental HRQoL scores predicted long-term survival in both univariate (RR = 3.58, CI: 1.99-6.45, p < 0.001) and multivariate adjusted for standard clinical information (RR = 2.17, CI: 1.17-4.01, p = 0.014). When analyzed with Cox regression, including alveolar bone loss and dental HRQoL, both factors, adjusted by clinical variables, were significant predictors of long-term survival: dental HRQoL (p = 0.007) and present alveolar bone loss (p = 0.034). Non-HNSCC disease-specific long-term survival predicted was also predicted when alveolar bone loss and dental HRQoL were analyzed simultaneously and adjusted for standard clinical information.

conclusionsThe degree of alveolar bone loss, as determined by OPG, and dental HRQoL both obtained at the time of HNSCC diagnosis, predicted long-term survival. When analyzed simultaneously, both factors remained significant in both univariate and multivariate analyses, adjusted by pertinent clinical variables, highlighting their unique prognostic value.

Indexed as

Alveolar Bone LossCarcinoma, Squamous CellHead and Neck NeoplasmsPeriodontitisQuality of LifeAdultAgedFemaleHumansMaleMiddle AgedOral HealthPrognosisRadiography, PanoramicSurvival RateCarcinomaHead and neckHealth-related quality of lifeHPVOral healthPeriodontitis

Identifiers

PMID39563313
PMCPMC11575175

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.