Evidence map›Paper›PMID 39563227›Full record

Trial reportBMC pregnancy and childbirth2024

Human papillomavirus infections during pregnancy and adverse pregnancy outcomes: a Scandinavian prospective mother-child cohort study.

Magdalena R Værnesbranden, Anne Cathrine Staff, Johanna Wiik, Katrine Sjøborg, Corina S Rueegg, Meryam Sugulle, Karin C Lødrup Carlsen, Berit Granum, Guttorm Haugen, Gunilla Hedlin and 9 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02449850 (Preventing Atopic Dermatitis and ALLergies in Children), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02449850 naactive not recruitingnot on this map

Preventing Atopic Dermatitis and ALLergies in Children

TypeinterventionalSponsorOslo University HospitalRan2014 to 2044Enrolled2,701ConditionsAtopic Dermatitis, Food Allergy in Children, Asthma, Rhinitis, AllergicArmsFood intervention, Skin care
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Magdalena R VærnesbrandenDepartment of Obstetrics and Gynecology, Østfold Hospital Trust, P.O. Box 300, Kalnes, Kalnes, 1714, Norway. c.m.r.varnesbranden@studmed.uio.no.
Anne Cathrine StaffFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Johanna WiikDepartment of Obstetrics and Gynecology, Østfold Hospital Trust, P.O. Box 300, Kalnes, Kalnes, 1714, Norway.
Katrine SjøborgDepartment of Obstetrics and Gynecology, Østfold Hospital Trust, P.O. Box 300, Kalnes, Kalnes, 1714, Norway.
Corina S RueeggOslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Meryam SugulleFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Karin C Lødrup CarlsenFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Berit GranumDepartment of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway.
Guttorm HaugenFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Gunilla HedlinAstrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Katarina HildeFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Björn NordlundAstrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Eva M RehbinderFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Knut RudiFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
Håvard O SkjervenFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Birgitte K SundetFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Cilla SöderhällAstrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Riyas VettukattilFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, P.O. Box 1702, Blindern, Oslo, 0316, Norway.
Christine M JonassenGenetic Unit, Centre for Laboratory Medicine, Østfold Hospital Trust, Kalnes, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman papillomaviruses are common in the urogenital tract amongst women of childbearing age. A few studies indicate a possible association between human papillomavirus infections in pregnancy and adverse pregnancy outcomes whilst other studies find no such association. We aimed to investigate the association between human papillomavirus infections during pregnancy and adverse pregnancy outcomes linked to placental dysfunction, including hypertensive disorders of pregnancy, gestational diabetes mellitus and newborns small for gestational age. MATERIALS AND

methodsPregnant women from the general population in Norway and Sweden were enrolled at the time of routine mid-gestational ultrasound examination. Urine samples collected at mid-gestation in 950 and at delivery in 753 participants, were analyzed for 28 human papillomavirus genotypes, including 12 high-risk genotypes. Participants completed electronic questionnaires at enrollment and medical records were reviewed for background characteristics and for the following adverse pregnancy outcomes: hypertensive disorders of pregnancy including gestational hypertension, preeclampsia, superimposed preeclampsia, eclampsia and Hemolysis Elevated Liver enzymes and Low Platelets (HELLP) syndrome, gestational diabetes mellitus, and newborns small for gestational age. Associations between adverse pregnancy outcomes and (a) any human papillomavirus, high-risk human papillomavirus and human papillomavirus genotype 16 infection at mid-gestation, (b) multiple genotype infections at mid-gestation, and (c) persisting infections during pregnancy were assessed with univariable and multivariable logistic regression models. Missing covariates were imputed using multiple imputation.

resultsAt mid-gestation, 40% (377/950) of women were positive for any of the 28 genotypes, 24% (231/950) for high-risk genotypes and human papillomavirus 16 was found in 6% (59/950) of the women. Hypertensive disorders of pregnancy was observed in 9% (83/950), gestational diabetes mellitus in 4% (40/950) and newborns small for gestational age in 7% (67/950). Human papillomavirus infection with any genotype, high-risk or human papillomavirus genotype 16 at mid-gestation was not associated with adverse pregnancy outcomes. No associations were found for multiple genotype infections at mid-gestation or persisting infections.

conclusionIn a general population of pregnant women, we found no evidence of human papillomavirus infections during pregnancy being associated with hypertensive disorders of pregnancy, gestational diabetes mellitus, or newborns small for gestational age.

trial registrationTrial registration The study is registered at ClincialTrials.gov; NCT02449850 on May 19th, 2015.

Indexed as

Diabetes, GestationalHypertension, Pregnancy-InducedPapillomavirus InfectionsPregnancy Complications, InfectiousPregnancy OutcomeAdultFemaleGenotypeHumansInfant, NewbornInfant, Small for Gestational AgeNorwayPapillomaviridaePre-EclampsiaPregnancyProspective StudiesGestational diabetes mellitusHuman papillomavirus and pregnancyHypertensive disorders of pregnancyPlacental dysfunction syndromesSmall for gestational age

Identifiers

PMID39563227
PMCPMC11575420

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.