Evidence map›Paper›PMID 39563005›Full record

ArticleThe Annals of otology, rhinology, and laryngology2025

Evaluation and Treatment of Acute Laryngeal Injury at Time of Tracheostomy for Prolonged Intubation.

Hannah Kavookjian, Emily Y Huang, Lee M Akst, Simon R Best, Alexander Hillel, Kevin Motz

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In one paragraph

Article in The Annals of otology, rhinology, and laryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hannah KavookjianDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0001-9506-8902
Emily Y HuangDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
Lee M AkstDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0002-8925-0545
Simon R BestDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0001-8699-033X
Alexander HillelDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
Kevin MotzDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0002-9255-7265

Funding

Targeting mTOR regulation of T-lymphocytes and fibroblasts in Laryngotracheal StenosisR01DC018567 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLEL, ALEXANDER · 2020 to 2024
$3.8M
Targeting pathologic macrophage activation through inhibition of MyD88 to attenuate laryngotracheal stenosisK23DC020988 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Kevin Motz · 2023 to 2026
$860k
NIDCD NIH HHS K23 DC020988NIDCD NIH HHS R01 DC018567
6 · The paper itself

Abstract

objectivesThe primary objective was to assess incidence and severity of acute laryngeal injury (ALgI) following intubation at time of tracheostomy using a proposed grading scale. The secondary objective was to evaluate what factors influence the rate of decannulation.

methodsSingle institution cohort study with review of prospectively maintained database including patients from October 2021 to October 2022 who underwent tracheostomy for prolonged intubation/critical illness. Severity of ALgI was graded as mild, moderate, or severe based on intraoperative endoscopic findings (laryngeal mucosal ulceration and/or granulation tissue). Rates of tracheostomy decannulation were collected as the secondary outcome measure.

resultsTwenty-eight patients met criteria for inclusion. About 60.7% (n = 17) patients were female. Average age was 59.0 ± 13.2 years old. Average body mass index was 32.3 ± 14.0 kg/m

conclusionsALgI is highly prevalent in patients undergoing tracheostomy for prolonged intubation. Severe injury is associated with reduced rates of decannulation. Direct laryngoscopy at time of tracheostomy is warranted to diagnose ALgI and guide interventions. Determining the extent of laryngeal injury is prognostic and could help tailor follow-up and management strategies. LEVEL OF EVIDENCE: 4.

Indexed as

Intubation, IntratrachealLarynxTracheostomyAdultAgedDevice RemovalFemaleHumansIncidenceLaryngoscopyMaleMiddle AgedRetrospective StudiesTime Factorsacute laryngeal injuryintubationlaryngotracheal stenosisposterior glottic stenosis

Identifiers

PMID39563005
PMCPMC12697569

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.