Evidence map›Paper›PMID 39562791›Full record

ArticleNature neuroscience2024

A top-down slow breathing circuit that alleviates negative affect in mice.

Jinho Jhang, Seahyung Park, Shijia Liu, David D O'Keefe, Sung Han

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
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  8. Respiratory-Limbic Coupling via a Thalamic Circuit Alleviates Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Breath-Counting Task Enhances the Sensitivity of Fear Acquisition.Behavioral sciences (Basel, Switzerland) · 2025
    Article
  15. Article
  16. A brainstem map of orofacial rhythms.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jinho JhangPeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Seahyung ParkPeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3021-6158
Shijia LiuPeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
David D O'KeefeResearch Development Department, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Sung HanPeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. sunghan@salk.edu.ORCID http://orcid.org/0000-0003-4519-0699

Funding

UC | UC San Diego | Kavli Institute for Brain and Mind, University of California, San Diego (KIBM, UCSD) IRGS 2020-1710
6 · The paper itself

Abstract

Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem respiratory networks, which hitherto have received little characterization. Here we identify in mice a top-down breathing pathway from dorsal anterior cingulate cortex (dACC) neurons to pontine reticular nucleus GABAergic inhibitory neurons (PnC

Indexed as

Gyrus CinguliOptogeneticsRespirationAffectAnimalsAnxietyGABAergic NeuronsMaleMedulla OblongataMiceMice, Inbred C57BLMice, TransgenicNeural Pathways

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.