Evidence map›Paper›PMID 39562789›Full record

ArticleScientific reports2024

The resolvin D2 and omega-3 polyunsaturated fatty acid as a new possible therapeutic approach for inflammatory bowel diseases.

Fabio Henrique Mendonça Chaim, Lívia Bitencourt Pascoal, Marina Moreira de Castro, Bruna Biazon Palma, Bruno Lima Rodrigues, João José Fagundes, Marciane Milanski, Luiz Roberto Lopes, Raquel Franco Leal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
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  6. Article
  7. Review
  8. Review
  9. A novelFrontiers in immunology · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Molecular dynamics of inflammation resolution: therapeutic implications.Frontiers in cell and developmental biology · 2025
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fabio Henrique Mendonça ChaimInflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-878, Brazil.
Lívia Bitencourt PascoalInflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-878, Brazil.
Marina Moreira de CastroInflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-878, Brazil.
Bruna Biazon PalmaInflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-878, Brazil.
Bruno Lima RodriguesInflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-878, Brazil.
João José FagundesInflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-878, Brazil.
Marciane MilanskiLaboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas (Unicamp), Limeira, São Paulo, Brazil.
Luiz Roberto LopesInflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-878, Brazil.
Raquel Franco LealInflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-878, Brazil. rafranco.unicamp@gmail.com.

Funding

Doctoral scholarship from the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil) Finance Code 001 for B.L.R.FAPESP (São Paulo Research Foundation) #2022/09393-4 for R.F.L.National Council for Scientific and Technological Development (CNPq) #302557/2021-0 for R.F.L.postdoctoral scholarship from Funding for Education, Research and Extension Support (FAEPEX) #2332/20 for L.B.P.Undergraduate scholarship from the FAPESP #2019/07095-3 for B.B.P.
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD) are idiopathic disorders characterized by chronic gastrointestinal inflammation. Given conventional therapies' adverse effects and clinical failures, novel approaches are being investigated. Recent studies have highlighted the role of specialized pro-resolving lipid mediators (SPMs) in the active resolution of chronic inflammation. In this regard, omega-3 fatty acid-derived Resolvin D2 (RvD2) appears to play a protective role in the pathophysiology of IBD. Therefore, we characterized the RvD2 pathway and its receptor expression in the intestinal mucosa of experimental colitis induced by dextran sulfate sodium. We also evaluated the preventive impact of an omega-3-enriched diet and the therapeutic efficacy of RvD2 compared with anti-TNF-α treatment. We found an increase in TNFα and IL22 expression and decreased levels of enzymes involved in RvD2 biosynthesis, such as PLA

Indexed as

Docosahexaenoic AcidsFatty Acids, Omega-3Inflammatory Bowel DiseasesAnimalsColitisDextran SulfateDisease Models, AnimalIntestinal MucosaMaleMiceMice, Inbred C57BLTumor Necrosis Factor-alphaDextran SulfateDocosahexaenoic AcidsFatty Acids, Omega-3resolvin D2Tumor Necrosis Factor-alphaChronic inflammationFatty acidInflammatory bowel diseaseOmega-3Pro-resolving lipid mediatorsResolvins

Identifiers

PMID39562789
PMCPMC11576872

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.