Evidence map›Paper›PMID 39562636›Full record

ArticleScientific reports2024

Complex immune network and regional consistency in the human gastric mucosa revealed by high-resolution spectral cytometry.

Ángel De Prado, Paloma Cal-Sabater, Aida Fiz-López, Sandra Izquierdo, Daniel Corrales, Francisco Pérez-Cózar, Juan H-Vázquez, Elisa Arribas-Rodríguez, Cándido Perez-Segurado, Álvaro Martín Muñoz and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Immunological mechanisms of autoimmune gastritis.Clinical and experimental medicine · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ángel De Prado *Mucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Paloma Cal-Sabater *Mucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Aida Fiz-LópezMucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Sandra IzquierdoGastroenterology Department, Hospital Clínico, Universitario (HCUV-SACYL), University of Valladolid, Valladolid, Spain.
Daniel CorralesPathology Department, Hospital Clínico, Universitario (HCUV-SACYL). Valladolid, Valladolid, Spain.
Francisco Pérez-CózarPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENYO), PTS, Granada, Spain.
Juan H-VázquezMucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Elisa Arribas-RodríguezMucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Cándido Perez-SeguradoMucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Álvaro Martín MuñozFlow Cytometry Facility. Unit of Excellence Instituto de Biología y Genética Molecular (IBGM), University of Valladolid-CSIC, Valladolid, Spain.
José A GarroteMucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Eduardo ArranzMucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Concepción MarañónPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENYO), PTS, Granada, Spain.
Sara Cuesta-SanchoMucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain.
Luis Fernández-SalazarGastroenterology Department, Hospital Clínico, Universitario (HCUV-SACYL), University of Valladolid, Valladolid, Spain.
David BernardoMucosal Immunology Lab, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Sanz y Forés 3., 47003, Valladolid, Spain. d.bernardo.ordiz@gmail.com.

Funding

Spanish Ministry of Science PID2019-104218RB-I00Unit of Excellence Institute of Biomedicine and Molecular Genetics, Junta de Castilla y Leon CCVC8485
6 · The paper itself

Abstract

The immune cellular landscape from the gastric mucosa remains largely unknown despite its relevance in several inflammatory conditions. Human gastric biopsies were obtained from the antrum, body and incisura from 10 individuals to obtain lamina propria mononuclear cells that were further characterized by spectral cytometry. Phenotypic hierarchical analyses identified a total of 52 different immune cell subsets within the human gastric mucosa revealing that T-cells (> 60%) and NK cells (> 20%) were the main populations. Within T-cells, CD4

Indexed as

Gastric MucosaAdultAgedBiopsyCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleFlow CytometryHelicobacter InfectionsHelicobacter pyloriHumansImmunophenotypingKiller Cells, NaturalMaleMiddle AgedGastricH. pyloriHumanImmunomeSpectral cytometryStomach

Identifiers

PMID39562636
PMCPMC11577052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.