Evidence map›Paper›PMID 39562595›Full record

ArticleScientific reports2024

Experts fail to reliably detect AI-generated histological data.

Jan Hartung, Stefanie Reuter, Vera Anna Kulow, Michael Fähling, Cord Spreckelsen, Ralf Mrowka

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Is this real? Susceptibility to deepfakes in machines and humans.Cognitive research: principles and implications · 2026
    Article
  3. Image fraud in nuclear medicine research.European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jan HartungInstitute for Physiology, Faculty of Medicine, University of Freiburg, 79108, Freiburg, Germany. jan.hartung@physiologie.uni-freiburg.de.ORCID 0000-0003-4110-3738
Stefanie ReuterThIMEDOP, Jena University Hospital, Nonnenplan 4, 07745, Jena, Germany.ORCID 0000-0002-3805-4632
Vera Anna KulowCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Freie Universität Berlin and Humboldt-Universität zu Berlin, Institut für Translationale Physiologie (CCM), Charitéplatz 1, 10117, Berlin, Germany.ORCID 0000-0002-4226-6697
Michael FählingCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Freie Universität Berlin and Humboldt-Universität zu Berlin, Institut für Translationale Physiologie (CCM), Charitéplatz 1, 10117, Berlin, Germany.ORCID 0000-0003-1079-5049
Cord SpreckelsenInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Bachstrase 18, 07743, Jena, Germany.
Ralf MrowkaDepartment of Internal Medicine III, Experimental Nephrology, Jena University Hospital, Nonnenplan 4, 07745, Jena, Germany. ralf.mrowka@med.uni-jena.de.ORCID 0000-0002-0991-3418

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AI-based methods to generate images have seen unprecedented advances in recent years challenging both image forensic and human perceptual capabilities. Accordingly, these methods are expected to play an increasingly important role in the fraudulent fabrication of data. This includes images with complicated intrinsic structures such as histological tissue samples, which are harder to forge manually. Here, we use stable diffusion, one of the most recent generative algorithms, to create such a set of artificial histological samples. In a large study with over 800 participants, we study the ability of human subjects to discriminate between these artificial and genuine histological images. Although they perform better than naive participants, we find that even experts fail to reliably identify fabricated data. While participant performance depends on the amount of training data used, even low quantities are sufficient to create convincing images, necessitating methods and policies to detect fabricated data in scientific publications.

Indexed as

AlgorithmsArtificial IntelligenceImage Processing, Computer-AssistedHumansArtificial intelligenceFraudHistologyMisconductPublishingStable diffusion

Identifiers

PMID39562595
PMCPMC11577117

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.