ArticleNature communications2024
Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Renal single-nucleus transcriptomic of a new model of cardiovascular-kidney-metabolic syndrome in aging swine.American journal of physiology. Renal physiology · 2026Article
- PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Functional Connections Between Insulin and Neurotrophin-3 in Hemodialysis Patients with Type 2 Diabetes.Current issues in molecular biology · 2026Review
- Molecular mechanisms and novel therapeutic targets of diabetic kidney disease.Chinese medical journal · 2026Review
- LncRNA MALAT1 drives diabetic kidney injury via Nrf2 suppression in glomerular endothelium.Scientific reports · 2026Article
- The cholesterol, high-density lipoprotein, and glucose index and its derived indices predict diabetic kidney disease development and progression: evidence from two nationwide cohorts and a biopsy-proven clinical cohort.Cardiovascular diabetology · 2026Article
- SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bidirectional regulation between mitochondrial metabolic reprogramming and epigenetic modifications in renal tubular epithelial cell injury of diabetic kidney disease.Frontiers in endocrinology · 2026Review
- Metabolic reprogramming in diabetic complications: mechanisms, pathologies, and molecular evidence from multi-organ studies.Frontiers in immunology · 2026Review
- Integrative Inflammation-Metabolism Indicator for Cardiovascular-Kidney-Metabolic Syndrome: Evaluating the C-Reactive Protein-Triglyceride Glucose Index for Risk Stratification and Progression Across Three National Cohorts.Mediators of inflammation · 2026Article
- Splice Isoforms of the Apoptosis Gene BCL-X Have Opposing Effects in Diabetic Kidney Disease: Potential Treatment Target and Prognostic Value.Journal of diabetes research · 2026Article
- The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients.Frontiers in endocrinology · 2026Article
- Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression.Renal failure · 2025Article
- A Novel Role of Hyaluronan and Its Membrane Receptors, CD44 and RHAMM, in Obesity-Related Kidney Pathology.Biomolecules · 2025Article
- Role of metallothionein 3 in diabetic nephropathy via interplay with HIF-1α.Diabetology international · 2025Article
- Spatial transcriptomics meets diabetic kidney disease: Illuminating the path to precision medicine.World journal of diabetes · 2025Review
- The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025Review
- Cluster Analysis in Diabetes Research: A Systematic Review Enhanced by a Cross-Sectional Study.Journal of clinical medicine · 2025Review
- Fibroblast growth factor 23 predicts incident diabetic kidney disease: A 4.6-year prospective study.Diabetes, obesity & metabolism · 2025Article
- Relationships Between Insulin Resistance Surrogate Indicators and Chronic Kidney Disease in Non-Diabetic Individuals: A Retrospective Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
Corrections and comments
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Authors and funding
26 authors.
Abigail C LayBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0001-5923-634X
Van Du T TranVital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0003-2074-5029
Viji NairDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Virginie BetinBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Jennifer A HurcombeBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Alexandra F BarringtonBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Robert Jp PopeBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Frédéric BurdetVital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0002-2923-827X
Florence MehlVital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0002-9619-1707
Dmytro KryvokhyzhaDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.ORCID 0000-0001-6498-1977
Abrar AhmadDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.ORCID 0000-0002-6308-952X
Matthew C SintonDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0003-1292-799X
Philip LewisProteomics Facility, University of Bristol, Bristol, UK.
Marieangela C WilsonProteomics Facility, University of Bristol, Bristol, UK.ORCID 0000-0001-6218-3533
Rajasree MenonDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6280-9639
Edgar OttoDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2387-9973
Kate J HeesomProteomics Facility, University of Bristol, Bristol, UK.ORCID 0000-0002-5418-5392
Mark IbbersonVital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0003-3152-5670
Helen C LookerChronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ, USA.
Robert G NelsonChronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ, USA.
Wenjun JuDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9136-8454
Matthias KretzlerDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Simon C SatchellBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0001-5276-4537
Maria F GomezDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.ORCID 0000-0001-6210-3142
Richard J M CowardBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK. Richard.Coward@bristol.ac.uk.ORCID 0000-0001-6183-2546
BEAt-DKD consortium
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3MCentral Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1MConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI KRETZLER, MATTHIAS · 2017 to 2021
$21.0MUniversity of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PENNATHUR, SUBRAMANIAM · 2008 to 2022
$12.9MKPMP Kidney Mapping and Atlas Project (KMAP)U01DK133090 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$10.4MIntegrated spatial interrogation of cellular and molecular signatures of human kidney diseaseU01DK114923 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Tarek Maurice Ashkar, Pierre C Dagher · 2022 to 2026
$5.4MSingle cell multiomic and spatial atlas of acute and chronic kidney injuryU01DK114933 · NIDDK · WASHINGTON UNIVERSITY · PI Sanjay Jain · 2022 to 2026
$5.0MSpatial Multi-Omics to Profile Metabolic Pathways for Kidney DiseaseU01DK114920 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Christopher R Anderton, Kumar Sharma · 2022 to 2026
$3.9MBoston Chronic Kidney Disease Research Biopsy CenterU01DK133092 · NIDDK · BOSTON MEDICAL CENTER · PI Sylvia E Rosas, Sushrut S. Waikar · 2022 to 2026
$3.5MMultimodal Imaging Mass Spectrometry and Spatial Omics for the Human KidneyU01DK133766 · NIDDK · VANDERBILT UNIVERSITY · PI Jeffrey M Spraggins · 2022 to 2026
$3.4MPREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)U01DK114907 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nir Hacohen, Jeffrey Benton Hodgin · 2022 to 2026
$3.2MSpatial Metabolomics for Human KidneysUH3DK114920 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHARMA, KUMAR · 2019 to 2021
$2.7MEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) BEAt DKD 115974Kidney Research UK INT_002_20220705NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK081943NIDDK NIH HHS U01 DK114866NIDDK NIH HHS U01 DK114907NIDDK NIH HHS U01 DK114908NIDDK NIH HHS U01 DK114920NIDDK NIH HHS U01 DK114923NIDDK NIH HHS U01 DK114933NIDDK NIH HHS U01 DK133081NIDDK NIH HHS U01 DK133090NIDDK NIH HHS U01 DK133091NIDDK NIH HHS U01 DK133092NIDDK NIH HHS U01 DK133093NIDDK NIH HHS U01 DK133095NIDDK NIH HHS U01 DK133097NIDDK NIH HHS U01 DK133113NIDDK NIH HHS U01 DK133766NIDDK NIH HHS U01 DK133768NIDDK NIH HHS U24 DK114886NIDDK NIH HHS U2C DK114886NIDDK NIH HHS UH3 DK114861NIDDK NIH HHS UH3 DK114866NIDDK NIH HHS UH3 DK114870NIDDK NIH HHS UH3 DK114907NIDDK NIH HHS UH3 DK114908NIDDK NIH HHS UH3 DK114915NIDDK NIH HHS UH3 DK114920NIDDK NIH HHS UH3 DK114923NIDDK NIH HHS UH3 DK114926NIDDK NIH HHS UH3 DK114933NIDDK NIH HHS UH3 DK114937RCUK | Medical Research Council (MRC) MR/K010492/1RCUK | Medical Research Council (MRC) MR/T002263/1RCUK | Medical Research Council (MRC) MR/W019582/1
Abstract
Diabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial, mesangial and proximal tubular cells) in insulin sensitive and resistant conditions, and perform simultaneous transcriptomics and proteomics for integrated analysis. Our data is further compared with bulk- and single-cell transcriptomic kidney biopsy data from early- and advanced-stage DKD patient cohorts. We identify several consistent changes (individual genes, proteins, and molecular pathways) occurring across all insulin-resistant kidney cell types, together with cell-line-specific changes occurring in response to insulin resistance, which are replicated in DKD biopsies. This study provides a rich data resource to direct future studies in elucidating underlying kidney signalling pathways and potential therapeutic targets in DKD.
Indexed as
Diabetic NephropathiesInsulin ResistanceKidneyBiopsyGene Expression ProfilingHumansProteomicsSignal TransductionTranscriptome
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