Evidence map›Paper›PMID 39562543›Full record

ArticleThe pharmacogenomics journal2024

Implementation of pharmacogenetic testing in pediatric oncology: barriers and facilitators assessment at eight Canadian academic health centres.

Jeanette Cooper, Joshua Pratt, Jamie Park, Christine Fahim, Jessica M Lovnicki, Gabriella S S Groeneweg, Bruce Carleton, Sharon Straus

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Unravelling the implementation of pharmacogenetic testing in Belgium.European journal of clinical pharmacology · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeanette CooperKnowledge Translation Program, Li Ka Shing Knowledge Institute, Unity Health Toronto, 209 Victoria Street, Toronto, M5B 1T8, ON, Canada.ORCID 0000-0002-5027-6334
Joshua PrattKnowledge Translation Program, Li Ka Shing Knowledge Institute, Unity Health Toronto, 209 Victoria Street, Toronto, M5B 1T8, ON, Canada.
Jamie ParkKnowledge Translation Program, Li Ka Shing Knowledge Institute, Unity Health Toronto, 209 Victoria Street, Toronto, M5B 1T8, ON, Canada.
Christine FahimKnowledge Translation Program, Li Ka Shing Knowledge Institute, Unity Health Toronto, 209 Victoria Street, Toronto, M5B 1T8, ON, Canada. christine.fahim@unityhealth.to.ORCID 0000-0002-6809-7027
Jessica M LovnickiDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Gabriella S S GroenewegDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Bruce CarletonDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-4485-4054
Sharon StrausKnowledge Translation Program, Li Ka Shing Knowledge Institute, Unity Health Toronto, 209 Victoria Street, Toronto, M5B 1T8, ON, Canada.

Funding

Genome British Columbia 272PGXGenome Canada (Génome Canada) 272PGXGouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) GP1-155872
6 · The paper itself

Abstract

Pharmacogenetic (PGx) testing can enhance drug safety, improve efficacy, and reduce the risk of toxicity. However, the implementation of PGx testing in Canadian pediatric oncology centers has been limited. To address this gap, the aim of this study was to assess the barriers and facilitators to implementing PGx testing for three oncology drugs in eight Canadian pediatric oncology centers and identify strategies that could be used to support PGx testing implementation. We used semi-structured interviews to identify barriers and facilitators to PGx testing and identified evidence-based strategies for PGx testing implementation through a mapping process that utilized the Theoretical Domains Framework, the Consolidated Framework for Implementation Research and the Behavior Change Wheel. We identified 38 facilitators and 26 barriers to implementation of PGx testing and mapped these to 6 implementation strategies.

Indexed as

Academic Medical CentersMedical OncologyPharmacogeneticsPharmacogenomic TestingAntineoplastic AgentsCanadaChildHumansNeoplasmsPediatricsAntineoplastic Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.