ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2025
Room temperature quantitative liquid concentration device and application to interleukins analysis in a B-cell culture medium.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- An automated endpoint control platform for a cyclone concentration pipette.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Physics-guided machine learning for real-time, non-contact quantification of liquid volume at micro litter under cyclone flow.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
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Abstract
In biological analysis and medical diagnosis, there is an increasing demand for improving the lower detection limit without deteriorating the quantitativity; however, it is usually challenging. In this study, we utilized a cyclone flow device and established a liquid concentration method. An air cyclone flow induced a liquid cyclone flow in the concentration devices and enhanced the air/liquid interface area, which allowed an effective concentration of liquid from mL to mL at room temperature. The heating temperature and actual temperature inside the liquid were investigated to know the cooling effect of evaporation. The collection efficiency of larger than 98% was confirmed with a standard solution. Finally, the analytical procedure to realize a quantitative concentration was established, and the concentration and quantification of interleukins (IL-8, IL-17, and IL-23) from the supernatant of the B-cell culture medium was demonstrated. The B-cell was stimulated with CD40L, and the supernatant was concentrated 27 times at maximum.
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