Evidence map›Paper›PMID 39562482›Full record

SynthesisEuropean geriatric medicine2025

Circulating irisin levels in patients with sarcopenia: a systematic review and meta-analysis.

Liangchuan Zhang, Yating Peng, Yuan Kong, Xue Zhang, Zetian Li, Hong Jia

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Liangchuan Zhang *School of Public Health, Southwest Medical University, Luzhou City, Sichuan Province, China.
Yating Peng *School of Public Health, Southwest Medical University, Luzhou City, Sichuan Province, China.
Yuan KongSchool of Public Health, Southwest Medical University, Luzhou City, Sichuan Province, China.
Xue ZhangSchool of Public Health, Southwest Medical University, Luzhou City, Sichuan Province, China.
Zetian LiSchool of Public Health, Southwest Medical University, Luzhou City, Sichuan Province, China.
Hong JiaSchool of Public Health, Southwest Medical University, Luzhou City, Sichuan Province, China. jhong_lz@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDuring the aging process, a decrease in irisin levels is associated with numerous bone and muscle diseases. This study aims to provide evidence of circulating irisin levels in patients with sarcopenia.

methodsThis systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard and the recommendations of the Cochrane Collaboration. A comprehensive search was conducted in PubMed, Embase, Web of Science databases, and other sources from their establishment until August 2023. The Review Manager software version 5.4 was used to calculate the standard mean difference (SMD). I

results12 studies involving 2133 participants who met the inclusion criteria were analyzed. We found that irisin levels were significantly lower in patients with sarcopenia (SMD: - 1.28; 95% CI - 1.65, - 0.90; I

conclusionNo matter the study area, study design, blood samples, or diagnostic criteria, the concentration of circulating irisin in patients with sarcopenia was lower than that in the control group.

Indexed as

FibronectinsSarcopeniaAgedBiomarkersHumansMuscle StrengthBiomarkersFibronectinsFNDC5 protein, humanIrisinMeta analysisOlder personsSarcopenia

Identifiers

PMID39562482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.