Evidence map›Paper›PMID 39562364›Full record

ArticleEuropean radiology2025

Embolization with gelatin foam in the management of vascularized retained products of conception: a multicenter study by the French Society of Cardiovascular Imaging.

Julien Ghelfi, Clément Marcelin, Alexandre Buisson, Eliott Mathieu, Loic Sentilhes, Thibault Thubert, Antoine Boizet, Marco Midulla, Hélène Kovacsik, Sébastien Caudron and 6 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Julien GhelfiUniversity of Grenoble-Alpes, Saint-Martin-d'Hères, France. jghelfi@chu-grenoble.fr.ORCID http://orcid.org/0000-0002-9039-6488
Clément MarcelinDepartment of Radiology, Bordeaux University Hospital, Bordeaux, France.
Alexandre BuissonUniversity of Grenoble-Alpes, Saint-Martin-d'Hères, France.
Eliott MathieuUniversity of Grenoble-Alpes, Saint-Martin-d'Hères, France.
Loic SentilhesDepartment of Obstetrics and Gynecology, Bordeaux University Hospital, Bordeaux, France.
Thibault ThubertDepartment of Obstetrics and Gynecology, Nantes University Hospital, Nantes, France.
Antoine BoizetDepartment of Radiology, Brest University Hospital, Brest, France.
Marco MidullaDepartment of Radiology, Dijon University Hospital, Dijon, France.
Hélène KovacsikDepartment of Radiology, Montpellier University Hospital, Montpellier, France.
Sébastien CaudronDepartment of Radiology, Limoges University Hospital, Limoges, France.
Francine ThouvenyDepartment of Radiology, Angers University Hospital, Angers, France.
Maxime BaratDepartment of Radiology, Cochin Hospital Assistance Publique des Hopitaux de Paris, Paris, France.
Julien FrandonDepartment Radiology, Nîmes University Hospital, Nîmes, France.
Pierre-Antoine BarralDepartment Radiology, Marseille University Hospital, Marseille, France.
Aurélie DeloucheUniversity of Grenoble-Alpes, Saint-Martin-d'Hères, France.
Arthur DavidDepartment Radiology, Nantes University Hospital, Nantes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesVascularized retained products of conception (vRPOC) are the most frequent cause of delayed hemorrhage after abortion, spontaneous miscarriage, or delivery. This study evaluated the efficacy of uterine artery embolization (UAE) with gelatin foam in the management of symptomatic of vRPOC. MATERIALS AND

methodsThis retrospective study included patients who underwent UAE with gelatin foam for vRPOCs with vaginal bleeding between January 2018 and December 2022 in 11 French university hospitals. Embolization was performed using either gelatin foam torpedoes or sludge. The primary endpoint was the clinical success of embolization (cessation of bleeding at approximately 1 month after UAE). The secondary objectives were the success of imaging (no persistent vRPOC at imaging follow-up), the safety of UAE, and the predictive factors of clinical and imaging failure.

resultsTwo hundred twenty-four patients (median age, 30.5 years ± 5.7 [standard deviation]) were included. Clinical success was achieved in 212 patients (94.2%). One hundred sixty-five patients had imaging follow-ups, among whom 12 patients (7.3%) had persistent vascularization. According to the SIR classification, 30 patients (13.4%) had minor complications, and two patients (0.8%) had major complications (endometritis n = 1; ischemic uterine necrosis n = 1). No predictive factors of clinical success were found, but the presence of a hypertrophic uterine artery (OR = 0.6 [0.38-0.97], p = 0.045) and the use of gelatin foam torpedoes (OR = 0.57 [0.42-0.77], p = 0.0012) were associated with a greater risk of persistent vRPOC on imaging control.

conclusionUAE with gelatin foam is safe and effective for treating hemorrhagic vRPOC. KEY POINTS: Question Uterine vacuity is frequently observed on ultrasound after UAE for vRPOC. Findings A hypertrophic uterine artery and the use of gelatin foam torpedoes are associated with an increased risk of persistent vRPOC. Clinical relevance Embolization with gelatin foam is efficient and safe for treating bleeding in vRPOC.

Indexed as

GelatinPlacenta, RetainedUterine Artery EmbolizationAdultFemaleFranceHumansPregnancyRetrospective StudiesTreatment OutcomeGelatinGelatin foamRetained products of conceptionUterine artery embolizationVaginal bleeding

Identifiers

PMID39562364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.