ArticleEuropean journal of neurology2025
Serum neurofilament light chain predicts disease severity in axonal variants of acute immune neuropathies: A retrospective monocentric cohort study.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Serum Galectin-3 as a biomarker in acute inflammatory polyradiculoneuropathies: a cohort study.Journal of neurology · 2026Article
- Neurofilament Light Chain Levels as Diagnostic and Prognostic Biomarkers in Guillain-Barré Syndrome: An Updated Systematic Review and Meta-Analysis.Neurology and therapy · 2025Article
- Response to "Acute myeloneuropathy after nitrous oxide use: multimodal diagnostic insights".Neurological research and practice · 2025Article
- Acute myeloneuropathy after nitrous oxide use: multimodal diagnostic insights : Response to research article: increase of nitrous oxide-induced neurological disorders - a German multicenter experience by Meißner et al.Neurological research and practice · 2025Article
- Reassessing the Role of the Neurofilament Light Chain in Guillain-Barre Syndrome: Issues in Diagnosis and Subgroup Classification.European journal of neurology · 2025Article
- Serum neurofilament light chain predicts disease severity in axonal variants of acute immune neuropathies: A retrospective monocentric cohort study.European journal of neurology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
background and purposeThe purpose was to explore the prognostic utility of neurofilament light chain (NfL) in patients with immune-mediated polyradiculoneuropathies (IMPs).
methodsThis retrospective monocentric study analysed serum and cerebrospinal fluid samples from patients diagnosed with IMP collected prior to treatment initiation. NfL concentrations were correlated with clinical outcomes, including F score and hospitalization duration.
resultsAmongst 115 IMP patients tested, baseline cerebrospinal fluid and serum NfL (sNfL) concentrations were higher in acute inflammatory axonal polyradiculoneuropathy (AIAP) than other IMP variants. In the AIAP cohort, a positive correlation was observed between baseline sNfL concentrations, F score and hospitalization duration. Multivariate linear regression analysis further supported the predictive relationship between elevated baseline sNfL concentrations and clinical outcomes. Using receiver operating characteristic analysis, a cut-off value for sNfL of 351 pg/mL was found to predict an F score >3 in AIAP with a sensitivity of 40% and specificity of 81.8%. AIAP patients with sNfL concentrations above this threshold required longer hospitalization (extended by 15 days). DISCUSSION: Our findings highlight the potential of baseline sNfL as an effective marker for distinguishing between IMP variants and predicting the prognosis of AIAP. Further validation may facilitate translation of sNfL into clinical practice, potentially identifying high-risk patients for tailored treatment approaches.
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