Evidence map›Paper›PMID 39562140›Full record

ArticleGenes & development2024

Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression.

Cyril S Anyetei-Anum, Mary P Leatham-Jensen, Geoffrey C Fox, B Rutledge Smith, Venkat R Chirasani, Krzysztof Krajewski, Brian D Strahl, Jill M Dowen, A Gregory Matera, Robert J Duronio and 1 more

Abstract read
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Cyril S Anyetei-AnumCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0002-6430-9694
Mary P Leatham-JensenIntegrative Program for Biological and Genome Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0002-6416-021X
Geoffrey C FoxCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-5898-0847
B Rutledge SmithDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Venkat R ChirasaniDepartment of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Krzysztof KrajewskiDepartment of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-7159-617X
Brian D StrahlCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0002-4947-6259
Jill M DowenCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-9776-1989
A Gregory MateraCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0002-6406-0630
Robert J DuronioCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-6469-6965
Daniel J McKayCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA; dmckay1@email.unc.edu.ORCID 0000-0001-8226-0604

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
UNC Initiative for Maximizing Student DevelopmentR25GM055336 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COOK, JEANETTE GOWEN, KASH, THOMAS L. · 1996 to 2023
$12.1M
Mechanisms of chromatin and transcriptional regulationR35GM126900 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian D Strahl · 2018 to 2026
$5.5M
NRSA in GeneticsT32GM135128 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay, JEFF J. SEKELSKY · 2020 to 2026
$5.1M
Role of histone PTMs in epigenetic control of metazoan transcription and RNA processingR35GM136435 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI A. Gregory Matera · 2020 to 2026
$4.7M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
Epigenetic Control of the Cell Cycle During Animal DevelopmentR35GM145258 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert J Duronio · 2022 to 2026
$2.3M
The role of genome folding in regulating gene expression and chromatin stateR35GM152103 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jill Dowen · 2024 to 2026
$1.3M
NCI NIH HHS P30 CA016086NIGMS NIH HHS R25 GM055336NIGMS NIH HHS R35 GM126900NIGMS NIH HHS R35 GM128851NIGMS NIH HHS R35 GM136435NIGMS NIH HHS R35 GM145258NIGMS NIH HHS R35 GM152103NIGMS NIH HHS T32 GM135128NIH HHS P40 OD018537
6 · The paper itself

Abstract

Tight control over cell identity gene expression is necessary for proper adult form and function. The opposing activities of Polycomb and trithorax complexes determine the on/off state of cell identity genes such as the Hox factors. Polycomb group complexes repress target genes, whereas trithorax group complexes are required for their expression. Although trithorax and its orthologs function as methyltransferases specific to histone H3 lysine 4 (H3K4), there is no direct evidence that H3K4 regulates Polycomb group target genes in vivo. Using histone gene replacement in

Indexed as

Drosophila ProteinsGene Expression Regulation, DevelopmentalHistonesLysinePolycomb-Group ProteinsAnimalsDrosophila melanogasterGene Expression RegulationMethylationMutationDrosophila ProteinsHistonesLysinePolycomb-Group ProteinschromatinDrosophilaepigenetic gene regulationhistone mutation

Identifiers

PMID39562140
PMCPMC11610931

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.