ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
High-Density Recording Reveals Sparse Clusters (But Not Columns) for Shape and Texture Encoding in Macaque V4.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Optotagging in primate cortex uncovers excitatory and inhibitory neuron specializations in form vision.Nature communications · 2026Article
- Curvature tuning in areas V2 and V4 of the developing macaque.bioRxiv : the preprint server for biology · 2026Article
- A modular neural circuit for computing the motion of objects.bioRxiv : the preprint server for biology · 2026Article
- Functional Clusters for Shape, Texture, and Motion Encoding in Macaque V2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Deep learning-driven characterization of single cell tuning in primate visual area V4 supports topological organization.bioRxiv : the preprint server for biology · 2025Article
- Functional clusters for shape, texture, and motion encoding in macaque V2.bioRxiv : the preprint server for biology · 2025Article
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Abstract
Macaque area V4 includes neurons that exhibit exquisite selectivity for visual form and surface texture, but their functional organization across laminae is unknown. We used high-density Neuropixels probes in two awake monkeys (one female and one male) to characterize the shape and texture tuning of dozens of neurons simultaneously across layers. We found sporadic clusters of neurons that exhibit similar tuning for shape and texture: ∼20% exhibited similar tuning with their neighbors. Importantly, these clusters were confined to a few layers, seldom "columnar" in structure. This was the case even when neurons were strongly driven and exhibited robust contrast invariance for shape and texture tuning. We conclude that functional organization in area V4 is not columnar for shape and texture stimulus features and in general organization may be at a coarser stimulus category scale (e.g., selectivity for stimuli with vs without 3D cues) and a coarser spatial scale (assessed by optical imaging), rather than at a fine scale in terms of similarity in single-neuron tuning for specific features. We speculate that this may be a direct consequence of the great diversity of inputs integrated by V4 neurons to build variegated tuning manifolds in a high-dimensional space.
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