Evidence map›Paper›PMID 39561978›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2025

Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults.

Bradley S Peterson, Sahar Delavari, Jonathan Sadik, Lars Ersland, Irene B Elgen, Siddhant Sawardekar, Ravi Bansal, Stein Magnus Aukland

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Article in Journal of child psychology and psychiatry, and allied disciplines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Bradley S PetersonInstitute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Sahar DelavariInstitute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jonathan SadikInstitute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Lars ErslandDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Irene B ElgenDivision of Psychiatry, Department of Child and Adolescent Psychiatry, Haukeland University Hospital, Bergen, Norway.
Siddhant SawardekarInstitute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Ravi BansalInstitute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Stein Magnus AuklandDepartment of Radiology, Haukeland University Hospital, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFifteen million infants annually are born prematurely, placing them at high risk for life-long adverse neurodevelopmental outcomes. Whether brain tissue abnormalities that accompany preterm birth persist into young adulthood and are associated with long-term cognitive or psychiatric outcomes is not known.

methodsFrom infancy into young adulthood, we followed a population-based sample of consecutively identified preterm infants and their matched term controls. The preterm group was born at an average gestational age of 31.5 ± 2.6 weeks. We obtained Diffusion Tensor Imaging scans and assessed cognitive and psychiatric outcomes in young adulthood, at a mean age of 19 (range 17.6-20.8) years. Usable data were acquired from 180 participants (89 preterm, 91 term).

resultsPreterm birth was associated with lower fractional anisotropy (FA) and higher average diffusion coefficient (ADC) values in deep white matter tracts of the internal capsule, cerebral peduncles, inferior frontal-occipital fasciculus, sagittal stratum and splenium of the corpus callosum, as well as in grey matter of the caudate, putamen and thalamus. A younger gestational age at birth accentuated these tissue abnormalities. Perinatal characteristics, including lower 5-min APGAR score, history of bronchopulmonary dysplasia, more days of oxygen supplementation and multiple births all increased ADC values in deep white matter tracts and grey matter throughout the brain. Preterm individuals had significantly lower full-scale IQ and more frequent lifetime psychiatric disorders. Those with psychiatric illnesses had significantly higher ADC and lower FA values throughout the deep posterior white matter.

conclusionsAbnormalities in brain tissue microstructure associated with preterm birth persist into young adulthood and likely represent disordered myelination and accompanying axonal pathology. These disturbances are associated with a higher likelihood of developing a psychiatric disorder by young adulthood. Brain tissue disturbances were accentuated in those born at younger gestational ages and in those with a history of perinatal complications associated with infection and inflammation.

Indexed as

BrainGray MatterInfant, PrematurePremature BirthWhite MatterAdolescentAdultDiffusion Tensor ImagingFemaleHumansInfant, NewbornLongitudinal StudiesMaleProspective StudiesYoung Adultdiffusion tensor imagingmagnetic resonance imagingPremature birthpreterm birth

Identifiers

PMID39561978
PMCPMC12018296

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