Evidence map›Paper›PMID 39561942›Full record

ArticleNitric oxide : biology and chemistry2025

Investigation of the susceptibility of clinical infection loads to nitric oxide antibacterial treatment.

Lori M Estes Bright, Arnab Mondal, Vicente Pinon, Anil Kumar, Stephen Thompson, Elizabeth J Brisbois, Hitesh Handa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nitric oxide : biology and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lori M Estes BrightSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Arnab MondalSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Vicente PinonPharmaceutical and Biomedical Sciences Department, College of Pharmacy, University of Georgia, Athens, GA, 30602, USA.
Anil KumarSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Stephen ThompsonSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Elizabeth J BrisboisSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Hitesh HandaSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, 30602, USA; Pharmaceutical and Biomedical Sciences Department, College of Pharmacy, University of Georgia, Athens, GA, 30602, USA. Electronic address: hhanda@uga.edu.

Funding

Nitric Oxide Functionalized Antibiotics to Combat Infections and Thrombosis for Extracorporeal Life SupportR01HL172496 · NHLBI · UNIVERSITY OF GEORGIA · PI Elizabeth Joy Brisbois, Hitesh Handa · 2024 to 2026
$1.5M
Bioinspired antifouling and thromboresistant polymers for blood-contacting interfacesR01HL151473 · NHLBI · UNIVERSITY OF GEORGIA · PI BRISBOIS, ELIZABETH JOY · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL151473NHLBI NIH HHS R01 HL172496
6 · The paper itself

Abstract

The persistent infection of medical devices by opportunistic pathogens has led to the development of antimicrobial medical device polymers. Nitric oxide (NO) is an endogenous antimicrobial molecule that is released through the degradation of synthetic donor molecules such as S-nitroso-N-acetylpenicillamine (SNAP) embedded into polymer membranes. It is hypothesized that the clinical success of these polymers is enhanced by the physiological release of NO and the consequent prevention of infection. However, such NO-releasing materials have never been evaluated against microbial loads that are commensurate with clinical infection levels. This study aimed to develop a standardized polymer film impregnated with SNAP that consistently releases NO and evaluates its efficacy against bacterial loads that represent clinical infection parameters. Microbial loads of 10

Indexed as

Anti-Bacterial AgentsNitric OxideNitric Oxide DonorsS-Nitroso-N-AcetylpenicillamineBacterial LoadEscherichia coliHumansMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsNitric OxideNitric Oxide DonorsS-Nitroso-N-AcetylpenicillamineAntibacterialClinical infectionMedical deviceNitric oxideS-nitroso-N-Acetylpenicillamine (SNAP)

Identifiers

PMID39561942
PMCPMC11729576

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.