Evidence map›Paper›PMID 39561920›Full record

ArticleContemporary clinical trials2025

INteractive survivorship program to improve health care REsources [INSPIRE]: A study protocol testing a digital intervention with stepped care telehealth to improve outcomes for adolescent and young adult survivors.

Jean C Yi, Sheri Ballard, Casey Walsh, Danielle N Friedman, Patricia A Ganz, Linda A Jacobs, Ann H Partridge, Sandra A Mitchell, Wendy M Leisenring, Karen L Syrjala and 1 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jean C YiFred Hutchinson Cancer Center, USA. Electronic address: jyi@fredhutch.org.
Sheri BallardFred Hutchinson Cancer Center, USA.
Casey WalshFred Hutchinson Cancer Center, USA.
Danielle N FriedmanMemorial Sloan Kettering Cancer Center, USA.
Patricia A GanzUniversity of California Los Angeles, USA.
Linda A JacobsAbramson Cancer Center, University of Pennsylvania, USA.
Ann H PartridgeDana-Farber Cancer Institute, USA.
Sandra A MitchellDivision of Cancer Control and Population Sciences, National Cancer Institute, USA.
Wendy M LeisenringFred Hutchinson Cancer Center, USA.
Karen L SyrjalaFred Hutchinson Cancer Center, USA.
K Scott BakerFred Hutchinson Cancer Center, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Improving Survivorship Care for Adolescents and Young Adults: a Mixed Methods Study of Alignment with the National Standards for Survivorship CareU01CA246659 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BAKER, KEVIN S · 2020 to 2025
$3.6M
NCI NIH HHS P30 CA008748NCI NIH HHS U01 CA246659
6 · The paper itself

Abstract

backgroundAdolescents and young adults with cancer (AYAs, ages 15-39 at the time of diagnosis) experience significant adverse health and psychosocial outcomes. AYAs live with emotional distress and health care demands that exceed those of their healthy peers but can have difficulty accessing care. Digitally delivered interventions are an attractive option for AYA survivors, a population that routinely utilizes online resources when seeking health information and support.

aimBy improving access to survivorship resources and support and strengthening health literacy and self-management skills, the INteractive Survivorship Program to Improve Health care REsources [INSPIRE] is designed to improve adherence to AYA health care guidelines and reduce cancer-related distress. We describe the protocol for a two-arm randomized controlled trial (RCT) testing the AYA-adapted INSPIRE program. METHODS/

designThe intervention includes an interactive mobile app, study website, and social media platforms, adding telehealth for those with continued distress, lower survivorship health care literacy, or poor engagement with the digital program at 6 weeks. Participants are randomized to INSPIRE or an active control. In the active control arm, survivors receive access to a study website with links to existing AYA survivor resources followed by delayed access to the INSPIRE program. Participants are not blinded; study staff not providing telehealth are blinded. The primary outcomes are cancer-related distress and health care adherence specific to second cancer and cardiometabolic screenings. DISCUSSION: If effective, the program is positioned for accelerated implementation to improve care for AYA survivors by using a scalable informatics-based administration and largely digital intervention program.

Indexed as

Cancer SurvivorsMobile ApplicationsTelemedicineAdolescentAdultFemaleHealth LiteracyHumansMaleNeoplasmsRandomized Controlled Trials as TopicSelf-ManagementSocial MediaSurvivorshipYoung AdultAdolescent and young adultcancer survivorDigital interventionStepped care

Identifiers

PMID39561920
PMCPMC11700757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.