Evidence map›Paper›PMID 39561882›Full record

ReviewFrontiers in neuroendocrinology2025

Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.

Shakeera L Walker, Erica R Glasper

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shakeera L WalkerDepartment of Neuroscience, The Ohio State University, Columbus, OH, 43210, United States; Neuroscience Graduate Program, The Ohio State University, Columbus, OH, 43210, United States.
Erica R GlasperDepartment of Neuroscience, The Ohio State University, Columbus, OH, 43210, United States; Neuroscience Graduate Program, The Ohio State University, Columbus, OH, 43210, United States; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, 43210, United States. Electronic address: erica.glasper@osumc.edu.

Funding

From Social Discruption to Neural Compromise: Establishing Markers and MediatorsR01NS125589 · NINDS · OHIO STATE UNIVERSITY · PI Erica R Glasper, Gretchen N Neigh · 2022 to 2026
$3.2M
NINDS NIH HHS R01 NS125589
6 · The paper itself

Abstract

Early-life stress (ELS) affects the development of prosocial behaviors and social-cognitive function, often leading to structural brain changes and increased psychosocial disorders. Recent studies suggest that mother- and father-child relationships independently influence social development in a sex-specific manner, but the effects of impaired father-child relationships are often overlooked. This review examines preclinical rodent studies to explore how parental neglect impacts neuroplasticity and social behaviors in offspring. We highlight that disruptions in maternal interactions may affect male pups more in uniparental rodents, while impaired paternal interactions in biparental rodents tend to impact female pups more. Due to limited research, the separate effects of maternal and paternal neglect on brain development and social behaviors in biparental species remain unclear. Addressing these gaps could clarify the sex-specific mechanisms underlying social and neurobiological deficits following parental neglect.

Indexed as

Adverse Childhood ExperiencesBehavior, AnimalBrainMaternal BehaviorPaternal BehaviorSex CharacteristicsSocial BehaviorStress, PsychologicalAnimalsFemaleHumansMaleNeuronal PlasticityBiparental rodentsEarly-life stressLimited bedding and nestingMaternal deprivationMaternal separationNeuroplasticityPaternal deprivationSocial behaviorsUniparental rodents

Identifiers

PMID39561882
PMCPMC11811932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.