Evidence map›Paper›PMID 39561579›Full record

ArticleBiomaterials advances2025

The biological effects of copper alloying in Zn-based biodegradable arterial implants.

Lea Morath, Shebeer A Rahim, Cole Baker, Deirdre E J Anderson, Monica T Hinds, Malgorzata Sikora-Jasinska, Lindy Oujiri, Lisa Leyssens, Greet Kerckhofs, Grzegorz Pyka and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Biodegradable Medical Implants: Reshaping Future Medical Practice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lea MorathDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA. Electronic address: lmmorath@mtu.edu.
Shebeer A RahimDepartment of Materials Science and Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Cole BakerDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA.
Deirdre E J AndersonDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA.
Monica T HindsDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA.
Malgorzata Sikora-JasinskaDepartment of Materials Science and Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Lindy OujiriDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Lisa LeyssensBiomechanics lab (MEED), Institute of Mechanics, Materials and Civil Engineering (iMMC), UCLouvain, Louvain-la-Neuve, Belgium; Pole of Morphology (MORF), Institute of Experimental and Clinical Research, UCLouvain, Brussels, Belgium; Department of Materials Engineering, KU Leuven, Heverlee, Belgium; Prometheus, Division for Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
Greet KerckhofsBiomechanics lab (MEED), Institute of Mechanics, Materials and Civil Engineering (iMMC), UCLouvain, Louvain-la-Neuve, Belgium; Pole Materials and Processes Engineering (IMAP), iMMC, UCLouvain, Louvain-la-Neuve, Belgium.
Grzegorz PykaDepartment of Metallurgy and Materials Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenberg 44, B-3001 Leuven, Belgium.
Alexander A OliverDepartment of Biomedical Engineering and Physiology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA.
Jaroslaw W DrelichDepartment of Materials Science and Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Jeremy GoldmanDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.

Funding

Biodegradable Metal Stent Alloys for Vascular ApplicationsR01HL168696 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jeremy Goldman, Monica T Hinds · 2023 to 2026
$2.8M
Novel Bioresorbable Vascular Scaffolds with Uniform BiodegradationR56HL163552 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI DRELICH, JAROSLAW W · 2023 to 2023
$462k
NHLBI NIH HHS R01 HL168696NHLBI NIH HHS R56 HL163552
6 · The paper itself

Abstract

Biodegradable metals based on zinc are being developed to serve as temporary arterial scaffolding. Although the inclusion of copper is becoming more prevalent for grain refinement in zinc alloys, the biological activity of the copper component has not been well investigated. Here, two ZnCu alloys (0.8 and 1.5 wt% Cu) with and without thermal treatment were investigated for their hemocompatibility and biocompatibility. The microstructure was examined using scanning electron microscopy and X-ray diffraction. Zn-1.5Cu was found to contain nearly double the amount of second phase (CuZn

Indexed as

Absorbable ImplantsAlloysCopperZincAnimalsArteriesBiocompatible MaterialsCorrosionMaleMaterials TestingRatsRats, Sprague-DawleyAlloysBiocompatible MaterialsCopperZinc

Identifiers

PMID39561579
PMCPMC11634653

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.