Evidence map›Paper›PMID 39560973›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2025

Impaired endothelial function contributes to cardiac dysfunction: role of mitochondrial dynamics.

Cristhian A Gutierrez-Huerta, Giovanni Quiroz-Delfi, Fathima Dhilhani Mohammed Faleel, Andreas M Beyer

Abstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Vascular (dys)function in the failing heart.Nature reviews. Cardiology · 2025
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cristhian A Gutierrez-HuertaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-3389-9652
Giovanni Quiroz-DelfiCardiovascular Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Fathima Dhilhani Mohammed FaleelCardiovascular Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Andreas M BeyerDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0001-9129-7492

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Critical role of Mitochondrial Fission/Fusion in Regulation of Microvascular Endothelial FunctionR01HL157025 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BEYER, ANDREAS M · 2021 to 2024
$2.1M
Mechanism of Chemotherapy Induced Microvascular Dysfunction in Cancer SurvivorsR01HL173549 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Andreas M Beyer · 2024 to 2026
$2.1M
Critical Role of Endothelial DRP1 in regulating metabolic, microvascular, and cardiac functionF31HL176057 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Cristhian A Gutierrez Huerta · 2024 to 2026
$163k
American Heart Association (AHA) DIVSUPHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 173549HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL157025NHLBI NIH HHS F31 HL176057NHLBI NIH HHS R01 HL157025NHLBI NIH HHS R01 HL173549NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

The endothelial microvasculature is essential for the regulation of vasodilation and vasoconstriction, and improved functioning of the endothelium is linked to improved outcomes for individuals with coronary artery disease (CAD). People with endothelial dysfunction exhibit a loss of nitric oxide (NO)-mediated vasodilation, achieving vasodilation instead through mitochondria-derived H

Indexed as

Endothelium, VascularMitochondrial DynamicsAnimalsCoronary Artery DiseaseEndothelial CellsHumansMitochondriaMitochondria, HeartNitric OxideReactive Oxygen SpeciesVasodilationNitric OxideReactive Oxygen Speciesendothelial cell biologyendothelial microvasculaturemicrocirculationmitochondrial dynamics

Identifiers

PMID39560973
PMCPMC12147231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.