Evidence map›Paper›PMID 39560905›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2025

Colorimetric quantification of vancomycin by highly active nitroxyl radical compounds.

Kyoko Sugiyama, Fumiya Sato, Kentaro Yoshida, Sachiko Komatsu, Tetsuya Ono, Yusuke Sasano, Yoshiharu Iwabuchi, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato

Abstract read
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In one paragraph

Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kyoko SugiyamaFaculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan.
Fumiya SatoFaculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan.
Kentaro YoshidaSchool of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan. k-yoshida@pha.ohu-u.ac.jp.ORCID http://orcid.org/0000-0002-4668-0908
Sachiko KomatsuFaculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan.
Tetsuya OnoSchool of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan.
Yusuke SasanoGraduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Yoshiharu IwabuchiGraduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Tsutomu FujimuraFaculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan.
Yoshitomo KashiwagiSchool of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan.
Katsuhiko SatoFaculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan. satok@tohoku-mpu.ac.jp.

Funding

Japan Society for the Promotion of Science 23K06068
6 · The paper itself

Abstract

Nitroxyl radicals, represented by 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO), are highly stable organic free radicals with unique properties and are used as functional molecules in various fields. However, TEMPO had low reactivity and sometimes did not provide enough response. Therefore, highly active nitroxyl radical compounds have been developed in which bicyclo and tricyclo structures stabilize the radicals. In this study, we found that nortropine N-oxyl (NNO), a type of highly active nitroxyl radical, can oxidize the 2,2'-dihydroxybiphenyl structure under physiological conditions, and succeeded in the colorimetric quantification of vancomycin containing 2,2'-dihydroxybiphenyl moieties in the molecular structure. The reaction took only a few minutes to complete and could be confirmed with the naked eye, with a quantitative range of 10-100 μM. High-performance analytical probes are expected to be developed that use highly active nitroxyl radical derivatives to replace TEMPO derivatives.

Indexed as

ColorimetryCyclic N-OxidesNitrogen OxidesVancomycinFree RadicalsCyclic N-OxidesFree RadicalsNitrogen OxidesnitroxylTEMPOVancomycinNitroxyl radicalNNOTEMPOVancomycin

Identifiers

PMID39560905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.