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SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025

Quality of life among obstructive sleep apnoea patients: a systematic review and meta-analysis of EQ-5D studies.

P Shirisha, Bhavani Shankara Bagepally, S Sajith Kumar, Bhanupriya Raghu

Abstract readSystematic ReviewMeta-Analysis
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In one paragraph

Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

P ShirishaICMR National Institute of Epidemiology, 2nd Main Rd, near Ambattur, Karmari Amman Nagar, TNHB Colony, Bhavani Nagar, Ayapakkam, Chennai, 600077, Tamil Nadu, India.
Bhavani Shankara BagepallyICMR National Institute of Epidemiology, 2nd Main Rd, near Ambattur, Karmari Amman Nagar, TNHB Colony, Bhavani Nagar, Ayapakkam, Chennai, 600077, Tamil Nadu, India. bagepally.bs@gov.in.ORCID http://orcid.org/0000-0003-0856-767X
S Sajith KumarICMR National Institute of Epidemiology, 2nd Main Rd, near Ambattur, Karmari Amman Nagar, TNHB Colony, Bhavani Nagar, Ayapakkam, Chennai, 600077, Tamil Nadu, India.
Bhanupriya RaghuICMR National Institute of Epidemiology, 2nd Main Rd, near Ambattur, Karmari Amman Nagar, TNHB Colony, Bhavani Nagar, Ayapakkam, Chennai, 600077, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive Sleep Apnoea (OSA) is a chronic condition which is associated with extreme daytime sleepiness, cognitive impairment, and other comorbidities and, hence, decreased quality of life (QoL). EQ-5D is one of the most widely used preference-based measures of QoL in patients with different diseases worldwide. This study aims to review the EQ-5D utility value of OSA across primary studies and perform a meta-analysis to derive pooled utility scores for OSA.

methodsA systematic review and meta-analysis of the EQ-5D scores of OSA patients adhering to PRISMA guidelines was conducted. Studies reporting EQ-5D utility scores among adult OSA patients were systematically searched across PubMed-Medline, Scopus, and Embase. Selected studies were systematically reviewed and we have assessed the studies for their quality. Meta-analysis was performed using a random-effect model with subgroup analysis to explore heterogeneity.

resultsThe search yielded 9,121 articles, of which twenty-eight studies were included in the synthesis. The pooled mean EQ-5D utility score was 0.73 (0.69 to 0.78) with high heterogeneity (I

conclusionThe synthesis revealed that the QoL is significantly lower in OSA, and the aggregated quantitative estimates of EQ-5D utility scores are essential inputs for economic evaluations.

Indexed as

Quality of LifeSleep Apnea, ObstructiveAdultFemaleHumansMaleMiddle AgedSurveys and QuestionnairesEQ-5DOSAQuality of lifeSystematic reviewUtility value

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.