Evidence map›Paper›PMID 39560855›Full record

ArticleHead and neck pathology2024

An Institutional Experience of Core Needle Biopsy with Cooperative Implementation by Pathologists and Head and Neck Oncologists in Salivary Gland Carcinoma.

Kenya Kobayashi, Seiichi Yoshimoto, Go Omura, Yoshifumi Matsumoto, Azusa Sakai, Kohtaro Eguchi, Toshihiko Sakai, Yoshitaka Honma, Fumihiko Matsumoto, Masahito Kawazu and 5 more

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In one paragraph

Article in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kenya KobayashiDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Seiichi YoshimotoDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Go OmuraDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Yoshifumi MatsumotoDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Azusa SakaiDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Kohtaro EguchiDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Toshihiko SakaiDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Yoshitaka HonmaDepartment of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Fumihiko MatsumotoDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Masahito KawazuDivision of Cell Therapy, Chiba Cancer Center, Chiba, Japan.
Yuki SaitoDepartment of Otolaryngology, Head and Neck Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Eigitsu RyoDivision of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan.
Akihiko YoshidaDivision of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan.
Yasushi YatabeDivision of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan.
Taisuke MoriDivision of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan. tamori@ncc.go.jp.

Funding

Japan Society for the Promotion of Science 22K09662Japan Society for the Promotion of Science 23K06476
6 · The paper itself

Abstract

purposeA major problem in establishing treatment strategies for salivary gland carcinomas is the difficulty of preoperative histologic subtyping. Core needle biopsy (CNB) allows the collection of a small, intact specimens from the tumor center for detailed analysis. We evaluated the efficacy and limitations of preoperative diagnosis with CNB specimens collected using a newly developed 20-gauge needle designed to popularize its use.

methodsPaired preoperative CNB and surgical specimens from 41 patients with malignant salivary gland tumors were retrospectively reviewed. A histologic typing platform, including morphologic and immunohistochemical evaluation and fluorescence in situ hybridization, was evaluated using CNB specimens. Biopsy specimen quality, diagnostic accuracy, and immunohistochemistry concordance rates between biopsy and surgical specimens were analyzed.

resultsIn 39 of the 41 patients, CNB provided high-quality specimens, enabling adequate morphologic, immunohistologic, and genomic analyses. In two patients, high-quality CNB specimens could not be obtained due to cystic fluid and tumor firmness. The overall accuracy of correct preoperative diagnosis was 75%. The success rate of histologic subtyping and HER2 immunostaining concordance between CNB and surgical specimens was lower in carcinoma ex-pleomorphic adenoma (CXPA) than in de novo carcinoma (histologic subtyping; CXPA vs de novo carcinoma 50% vs 89%, p = 0.016, HER2 concordance; salivary duct carcinoma [SDC] ex-PA vs de novo SDC 16% vs 100%, p = 4.66E-03). No recurrence occurred due to tumor seeding after CNB.

conclusionsHighly accurate histologic subtyping of salivary gland carcinomas can be performed by preoperative CNB; however, specificity can be more challenging in pathologically heterogenous tumors.

Indexed as

Salivary Gland NeoplasmsAdultAgedAged, 80 and overBiopsy, Large-Core NeedleCarcinomaFemaleHumansMaleMiddle AgedPathologistsRetrospective StudiesYoung AdultCore needle biopsyHistologic subtypePreoperative pathologic diagnosisSOX10Tumor heterogeneity

Identifiers

PMID39560855
PMCPMC11576705

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