Evidence map›Paper›PMID 39560751›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Antiplasmodial potential of compounds isolated from Ziziphus mucronata and their binding to Plasmodium falciparum HGXPRT using biophysical and molecular docking studies.

Kgaugelo J Masia, Ndumiso N Mhlongo, Ofentse J Pooe, Mohammed A Ibrahim, Abidemi P Kappo, Mthokozisi B C Simelane

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Tropical life sciences research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kgaugelo J MasiaDepartment of Biochemistry, Faculty of Science, University of Johannesburg, Auckland Park Kingsway Campus, Johannesburg, 2006, South Africa.
Ndumiso N MhlongoDiscipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, 4000, South Africa.
Ofentse J PooeSchool of Life Sciences, University of KwaZulu-Natal, Durban, 4000, Westville, South Africa.
Mohammed A IbrahimDepartment of Biochemistry, Ahmadu Bello University, Zaria, 810107, Nigeria.
Abidemi P KappoDepartment of Biochemistry, Faculty of Science, University of Johannesburg, Auckland Park Kingsway Campus, Johannesburg, 2006, South Africa.
Mthokozisi B C SimelaneDepartment of Biochemistry, Faculty of Science, University of Johannesburg, Auckland Park Kingsway Campus, Johannesburg, 2006, South Africa. msimelane@uj.ac.za.

Funding

The National Research Foundation TTK210219587174
6 · The paper itself

Abstract

The increasing resistance of Plasmodium parasites to currently available antiplasmodial therapies poses a significant challenge in treating malaria. Since ancient times, plants have served as a primary source of novel pharmacologically active compounds for drug development. Therefore, this study aimed to explore the antiplasmodial properties of pentacyclic triterpenes isolated from Ziziphus mucronata bark, with an emphasis on their mechanism of action. Dichloromethane and ethyl acetate extracts of the stem bark were subjected to silica gel column chromatography, which led to the isolation of three known triterpenoids: betulinic acid, methyl betulinate, and lupeol. The compounds were then evaluated for antiplasmodial activity against Plasmodium falciparum NF54 strains using the Plasmodium lactate dehydrogenase (pLDH) assay. In silico evaluation of the isolated compounds was conducted through molecular docking and further validated with in vitro experiments against a purified protein target, Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT). Betulinic acid, methyl betulinate, and lupeol exhibited potent antiplasmodial activities with IC

Indexed as

AntimalarialsHypoxanthine PhosphoribosyltransferasePlant ExtractsPlasmodium falciparumZiziphusBetulinic AcidLupanesMolecular Docking SimulationPentacyclic TriterpenesTriterpenesAntimalarialsBetulinic AcidHypoxanthine PhosphoribosyltransferaseLupaneslupeolPentacyclic TriterpenesPlant ExtractsTriterpenesBetulinic acidIn silico studiesLupeolMethyl betulinatePfHGXPRT

Identifiers

PMID39560751
PMCPMC11985687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.