Evidence map›Paper›PMID 39560721›Full record

ArticleArchives of microbiology2024

Potential role of the antimicrobial peptide Tachyplesin III in regulating nontypeable Haemophilus influenzae-induced inflammation in airway epithelial cells.

Pornpimon Jantaruk, Sittiruk Roytrakul, Anchalee Sistayanarain, Duangkamol Kunthalert

Abstract read
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In one paragraph

Article in Archives of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pornpimon JantarukDepartment of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Sittiruk RoytrakulFunctional Proteomics Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand.
Anchalee SistayanarainDepartment of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Duangkamol KunthalertDepartment of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand. duangkamolk@nu.ac.th.

Funding

The Royal Golden Jubilee Ph.D. (RGJ-PHD) Program Scholarship PHD/0050/2559
6 · The paper itself

Abstract

The respiratory bacterium nontypeable (non-encapsulated) Haemophilus influenzae (NTHi) is a key pathogen driving exacerbations in chronic obstructive pulmonary disease (COPD), and is associated with an excessive airway inflammation. Increasing issues with tolerance and unwanted side effects of existing pharmaceuticals present an urgent need for new, effective and minimally toxic therapeutic options. This study aimed to investigate the potential role of Tachyplesin III, an antimicrobial peptide derived from the hemolysates of Southeast Asian horseshoe crabs, in regulating NTHi-induced airway inflammation. The results revealed that Tachyplesin III effectively inhibited the production of IL-1β in NTHi-stimulated human lung epithelial cells (A549), without causing cytotoxic effects. Additionally, Tachyplesin III significantly reduced TNF-α, PGE

Indexed as

Epithelial CellsHaemophilus influenzaeInflammationA549 CellsAnimalsAntimicrobial Cationic PeptidesAntimicrobial PeptidesCyclooxygenase 2DinoprostoneDNA-Binding ProteinsHaemophilus InfectionsHumansInterleukin-1betaNF-kappa BNitric OxidePeptides, CyclicAntimicrobial Cationic PeptidesAntimicrobial PeptidesCyclooxygenase 2DinoprostoneDNA-Binding ProteinsInterleukin-1betaNF-kappa BNitric OxidePeptides, Cyclictachyplesin peptide, Tachypleus tridentatusTumor Necrosis Factor-alphaAirway epithelial cellsInflammationNontypeable Haemophilus influenzaeNTHiTachyplesin III

Identifiers

PMID39560721

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.