Evidence map›Paper›PMID 39560705›Full record

ArticleNeurosurgical review2024

P4HA2 knockdown prevents the progression of intracranial aneurysm by inducing prolyl hydroxylation of YAP1.

Lirong Li, Jingchun Wang, Shaohua Ren, Xudong Hao

Abstract read
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In one paragraph

Article in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lirong LiDepartment of Neurosurgery, Shanxi Provincial People's Hospital, No. 29 Shuangtasi Street, Yingze District, Taiyuan, Shanxi, 030012, China. lilirong999@yeah.net.
Jingchun WangDepartment of Neurosurgery, Shanxi Provincial People's Hospital, No. 29 Shuangtasi Street, Yingze District, Taiyuan, Shanxi, 030012, China.
Shaohua RenDepartment of Neurosurgery, Shanxi Provincial People's Hospital, No. 29 Shuangtasi Street, Yingze District, Taiyuan, Shanxi, 030012, China.
Xudong HaoDepartment of Neurosurgery, Shanxi Provincial People's Hospital, No. 29 Shuangtasi Street, Yingze District, Taiyuan, Shanxi, 030012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolyl 4-hydroxylase subunit alpha 2 (P4HA2), a key enzyme modulating the post-transcription of proteins, was reported to be a causative gene in IA. Nevertheless, the exact function and mechanism of P4HA2 in the formation and rupture of IA is elusive. The current study first explored the expression of P4HA2 and its association with the clinicopathological demonstrations in patients with IA. In addition, an in vitro model of IA was established using H

Indexed as

Adaptor Proteins, Signal TransducingIntracranial AneurysmTranscription FactorsYAP-Signaling ProteinsApoptosisCell MovementDisease ProgressionFemaleGene Knockdown TechniquesHumansHydrogen PeroxideHydroxylationMaleMiddle AgedMuscle, Smooth, VascularMyocytes, Smooth MuscleAdaptor Proteins, Signal TransducingHydrogen PeroxideProcollagen-Proline DioxygenaseTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsIntracranial aneurysmP4HA2Prolyl hydroxylationYAP1

Identifiers

PMID39560705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.