Evidence map›Paper›PMID 39560651›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

The mechanism of allosteric regulation of calcium-independent phospholipase A

Varnavas D Mouchlis, Yuan-Hao Hsu, Daiki Hayashi, Jian Cao, Sheng Li, J Andrew McCammon, Edward A Dennis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Varnavas D MouchlisDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.ORCID 0000-0002-4235-1867
Yuan-Hao HsuDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.
Daiki HayashiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.
Jian CaoDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.
Sheng LiDepartment of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
J Andrew McCammonDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.ORCID 0000-0003-3065-1456
Edward A DennisDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601.ORCID 0000-0003-3738-3140

Funding

ACTION OF LIPOLYTIC ENZYMESR01GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 1985 to 2020
$7.3M
Action of Lipolytic EnzymesR35GM139641 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EDWARD A DENNIS · 2021 to 2026
$2.6M
NIGMS NIH HHS R01 GM020501NIGMS NIH HHS R35 GM139641
6 · The paper itself

Abstract

Group VIA calcium-independent phospholipase A

Indexed as

Adenosine TriphosphateCalciumCalmodulinMolecular Dynamics SimulationAllosteric RegulationAnkyrinsBinding SitesHumansMutagenesis, Site-DirectedPhospholipases A2, Calcium-IndependentProtein BindingProtein DomainsAdenosine TriphosphateAnkyrinsCalciumCalmodulinPhospholipases A2, Calcium-Independentdrug discoveryHDX-MSlipidomicsmolecular dynamicsphospholipases

Identifiers

PMID39560651
PMCPMC11621833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.