Evidence map›Paper›PMID 39560641›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

CD4

Alexia Vereertbrugghen, Manuela Pizzano, Agostina Cernutto, Florencia Sabbione, Irene A Keitelman, Douglas Vera Aguilar, Ariel Podhorzer, Federico Fuentes, Celia Corral-Vázquez, Mauricio Guzmán and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The Impact of Aging and Sex on Corneal Nerve Density and Function.Investigative ophthalmology & visual science · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexia VereertbrugghenInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.ORCID 0000-0002-4210-2916
Manuela PizzanoInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Agostina CernuttoInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Florencia SabbioneInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Irene A KeitelmanInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Douglas Vera AguilarInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Ariel PodhorzerFlow Cytometry Unit, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.ORCID 0000-0002-4861-5333
Federico FuentesConfocal Microscopy Unit, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Celia Corral-VázquezTranslational Clinical Research Program, Hospital del Mar Research Institute, Barcelona 08003, Spain.
Mauricio GuzmánTranslational Clinical Research Program, Hospital del Mar Research Institute, Barcelona 08003, Spain.ORCID 0000-0002-4447-2064
Mirta N GiordanoInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Analía TrevaniInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Cintia S de PaivaOcular Surface Center, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-9057-5494
Jeremías G GallettiInnate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.ORCID 0000-0002-5118-2540

Funding

Effects of cornea epithelial barrier disruption on the cornea trigeminal neural circuitU01EY034692 · NEI · BAYLOR COLLEGE OF MEDICINE · PI RUI CHEN, CINTIA S. DE PAIVA · 2022 to 2026
$5.9M
Investigating the anti-inflammatory mechanisms of calorie restriction in the aged lacrimal glandR01EY035333 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI CINTIA S. DE PAIVA, Helen P. Makarenkova · 2024 to 2026
$2.1M
Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Agencia I + D + i) PICT 2018-02911 PICT 2020-00138 PICT 2021-00109NEI NIH HHS R01 EY035333NEI NIH HHS U01 EY034692Wellcome TrustWellcome Trust (WT) 221859/Z/20/Z
6 · The paper itself

Abstract

Dry eye disease (DED) is characterized by a dysfunctional tear film in which the corneal epithelium and its abundant nerves are affected by ocular desiccation and inflammation. Although adaptive immunity and specifically CD4

Indexed as

CD4-Positive T-LymphocytesDisease Models, AnimalDry Eye SyndromesEpithelium, CornealAdoptive TransferAnimalsCorneaCytokinesFemaleMiceMice, Inbred C57BLTearsCytokinesautoimmunityCD4 T cellscorneaneuropathyocular surface

Identifiers

PMID39560641
PMCPMC11621630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.