ArticleRadiology2024
Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at
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Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
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Who cites it
11 citing papers in PubMed.
- In vivo multimodal PET/MRI imaging and plasma biomarkers implicate glymphatic dysfunction linking neuroinflammation to tau pathology in the early Alzheimer's disease continuum.European journal of nuclear medicine and molecular imaging · 2026Article
- Advancing Alzheimer's disease research in China: insights, innovations, and future directions from the chinese preclinical Alzheimer's disease study (CPAS).Molecular psychiatry · 2026Review
- Impaired glymphatic function is associated with synaptic loss in cognitive impairment.European journal of nuclear medicine and molecular imaging · 2026Article
- Enhancing diagnosis of mild cognitive impairment through brain-heart-gut metabolic networks in whole-body PET imaging.Cell reports. Medicine · 2026Article
- Plasma growth-associated protein 43 correlates with synaptic loss in Alzheimer's disease.Cell reports. Medicine · 2025Article
- Exploring structure-function coupling in alzheimer's disease: bridging neuroimaging, AI, and policy for future insights.European journal of nuclear medicine and molecular imaging · 2025Article
- Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer's disease: associations with Aβ, tau, synaptic proteins and APOE ε4.Translational neurodegeneration · 2025Article
- Spotlight on Alzheimer's disease and related dementias research in East Asia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Plasma biomarkers as core mediators in functional network abnormalities: Evidence from a two-cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Validation of the robustness of blood-based biomarkers for predicting amyloid-β positivity in Chinese populations.Frontiers in aging neuroscience · 2025Article
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Authors and funding
18 authors.
Junhao Wu *From the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0002-1695-0735
Binyin Li *From the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0003-1953-382X
Jie WangFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0003-4338-2873
Qi HuangFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0002-9425-6618
Xing ChenFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).
Zhiwen YouFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).
Kun HeFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0002-6969-3488
Qihao GuoFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).
Songye LiFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0002-6096-8756
Yiyun Henry HuangFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).
Tengfei GuoFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0003-2982-0865
Wenlin DaiFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0002-4858-1145
Weiwei XiangFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0009-0003-1545-0872
Weihuang ChenFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0009-0001-2122-6397
Dake YangFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).
Jun ZhaoFrom the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0002-9887-5512
Yihui Guan *From the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0003-3001-7965
Fang Xie *From the Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China (J. Wu, J. Wang, Q.H., K.H., Y.G., F.X.); Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.L.); Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (X.C., Z.Y., J.Z.); Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China (Q.G.); PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (S.L., Y.H.H.); Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China (T.G.); Center for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China (W.D.); and Shanghai Conlight Medical Laboratory, Shanghai, China (W.X., W.C., D.Y.).ORCID 0000-0003-2667-281X
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Synaptic loss is an important factor in Alzheimer disease (AD); however, blood assays that conveniently and rapidly reflect changes in synaptic density are lacking. Purpose To correlate multiple potential synaptic blood markers with synaptic density measured using
Indexed as
BrainGlial Fibrillary Acidic Proteintau ProteinsAgedAlzheimer DiseaseBiomarkersCognitive DysfunctionFemaleFluorine RadioisotopesHumansMaleMiddle AgedPositron-Emission TomographyPositron Emission Tomography Computed TomographyProspective StudiesRadiopharmaceuticalsBiomarkersFluorine-18Fluorine RadioisotopesGlial Fibrillary Acidic ProteinMAPT protein, humanRadiopharmaceuticalstau Proteins
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