Evidence map›Paper›PMID 39560402›Full record

ArticleInfection and immunity2024

C-di-AMP accumulation disrupts glutathione metabolism in

Cheta Siletti, Matthew Freeman, Hung H Dang, Zepeng Tu, David M Stevenson, Daniel Amador-Noguez, John-Demian Sauer, TuAnh N Huynh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Listeriosis.Nature reviews. Disease primers · 2025
    Review
  2. Article
  3. Infant-Type Bifidobacteria as Biocontrol Agents: SuppressingThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Cheta SilettiMicrobiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-4524-0556
Matthew FreemanDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Hung H DangFood Science Department, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Zepeng TuFood Science Department, University of Wisconsin-Madison, Madison, Wisconsin, USA.
David M StevensonDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Daniel Amador-NoguezDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-3568-3070
John-Demian SauerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-9367-794X
TuAnh N HuynhFood Science Department, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-7313-6166

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
Identification and Characterization of Genes Required for Listeria monocytogenes Cytosolic SurvivalR01AI137070 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SAUER, JOHN-DEMIAN · 2018 to 2022
$2.9M
Identification and Characterization of Genes Required for Listeria monocytogenes Cytosolic SurvivalR01AI184369 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI JOHN-DEMIAN SAUER · 2024 to 2026
$2.1M
The regulation of c-di-AMP homeostasis and signaling in bacteriaR35GM147519 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Tu Anh Huynh · 2022 to 2026
$1.7M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI137070HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM147519NIAID NIH HHS R01 AI137070NIAID NIH HHS R01 AI184369NIAID NIH HHS T32 AI055397NIGMS NIH HHS R35 GM147519NIGMS NIH HHS T32 GM008692
6 · The paper itself

Abstract

C-di-AMP homeostasis is critical for bacterial stress response, cell wall integrity, and virulence. Except for osmotic stress response, the molecular mechanisms underlying other processes are not well defined. A

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialGlutathioneListeria monocytogenesAnimalsDinucleoside PhosphatesDisease Models, AnimalListeriosisMicePeptide Termination FactorsVirulenceBacterial Proteinscyclic diadenosine phosphateDinucleoside PhosphatesGlutathionePeptide Termination FactorsPrfA protein, Listeria monocytogenesc-di-AMPglutathioneListeria monocytogenes

Identifiers

PMID39560402
PMCPMC11629612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.