Evidence map›Paper›PMID 39560366›Full record

ArticleThe journal of physical chemistry. B2024

Modeling and NMR Data Elucidate the Structure of a G-Quadruplex-Ligand Interaction for a Pu22T-Cyclometalated Iridium(III) System.

Carly R Reed, Scott D Kennedy, Rachel H Horowitz, Anees Mohammed Keedakkatt Puthenpeedikakkal, Harry A Stern, David H Mathews

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carly R ReedDepartment of Chemistry and Biochemistry, SUNY Brockport, Brockport, New York 14420, United States.ORCID 0000-0003-0268-1017
Scott D KennedyDepartment of Biochemistry & Biophysics and Center for RNA Biology, University of Rochester Medical Center, Rochester, New York 14642, United States.ORCID 0000-0001-9792-8726
Rachel H HorowitzDepartment of Chemistry and Biochemistry, SUNY Brockport, Brockport, New York 14420, United States.
Anees Mohammed Keedakkatt PuthenpeedikakkalDepartment of Biochemistry & Biophysics and Center for RNA Biology, University of Rochester Medical Center, Rochester, New York 14642, United States.
Harry A SternOrogen Therapeutics, 12 Gill Street Suite 4200, Woburn, Massachusetts 01801, United States.
David H MathewsDepartment of Biochemistry & Biophysics and Center for RNA Biology, University of Rochester Medical Center, Rochester, New York 14642, United States.ORCID 0000-0002-2907-6557

Funding

RNA Structure Modeling Using Physics and Sequence ComparisonR35GM145283 · NIGMS · UNIVERSITY OF ROCHESTER · PI DAVID H. MATHEWS · 2022 to 2026
$2.7M
NIGMS NIH HHS R35 GM145283
6 · The paper itself

Abstract

Cyclometalated iridium(III) complexes are increasingly being developed for application in G-quadruplex (GQ) nucleic acid biosensors. We monitored the interactions of a GQ structure with an iridium(III) complex by nuclear magnetic resonance (NMR) titrations and subsequently compared the binding site inferred from NMR with binding positions modeled by molecular docking and molecular dynamics simulations. When titrated into a solution of G-quadruplex

Indexed as

G-QuadruplexesIridiumMolecular Docking SimulationMolecular Dynamics SimulationBinding SitesCoordination ComplexesLigandsMagnetic Resonance SpectroscopyCoordination ComplexesIridiumLigands

Identifiers

PMID39560366
PMCPMC11613442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.