Evidence map›Paper›PMID 39559905›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Long-term effects of collaborative dementia care on quality of life and caregiver well-being.

Katherine L Possin, Sarah Dulaney, Alissa B Sideman, Andrew J Wood, I Elaine Allen, Stephen J Bonasera, Jennifer J Merrilees, Kirby Lee, Winston Chiong, Tamara L Braley and 10 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Effects of a virtual iSupport Program on carers and people with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  3. Long-term effects of collaborative dementia care on quality of life and caregiver well-being.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  4. Review
  5. Bridging the diagnostic gap: Expanding dementia care navigation for timely diagnosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Katherine L PossinWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Sarah DulaneyWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Alissa B SidemanThe Global Brain Health Institute, University of California, San Francisco, California, USA.
Andrew J WoodWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
I Elaine AllenThe Global Brain Health Institute, University of California, San Francisco, California, USA.
Stephen J BonaseraDepartment of Geriatrics, Gerontology and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Jennifer J MerrileesWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Kirby LeeDepartment of Clinical Pharmacy, University of California, San Francisco, California, USA.
Winston ChiongWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Tamara L BraleyDepartment of Geriatrics, Gerontology and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Sarah HooperUCSF/UC Law SF Consortium, UC Law, San Francisco, California, USA.
Mia KanzawaSchool of Public Health, Berkeley, California, USA.
Rosalie GearhartWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Helen MedsgerFamily Advisory Council, University of California, San Francisco, California, USA.
Krista L HarrisonPhilip R. Lee Institute for Health Policy Studies, University of California, San Francisco, California, USA.
Lauren J HuntThe Global Brain Health Institute, University of California, San Francisco, California, USA.
Rachel E KiekhoferWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Christopher ChowWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Bruce L MillerWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Elan L GutermanWeill Institute for Neurosciences, University of California, San Francisco, California, USA.

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI W. JOHN BOSCARDIN · 2013 to 2026
$19.9M
The Care Ecosystem Response to COVID-19: Accelerating Research on Dementia Care that Meets the Needs of Caregivers and Persons with Dementia during COVID-19R01AG074710 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2022 to 2024
$9.1M
The Care Ecosystem: Navigating patients and caregivers through stages of dementia careR01AG056715 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2017 to 2021
$6.0M
Hospice Use in Older Adults with Alzheimer's Disease and Related Dementias: Patterns, Policies, and Caregiver ExperiencesK76AG074924 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, LAUREN · 2021 to 2025
$1.1M
Mapping the Dynamics of Caregiver Burden in Alzheimer's DiseaseK01AG059840 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIDEMAN, ALISSA BERNSTEIN · 2020 to 2024
$652k
NIA NIH HHS K01 AG059840NIA NIH HHS K76 AG074924NIA NIH HHS P30 AG044281NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG056715NIA NIH HHS R01AG056715 R01AG074710NIA NIH HHS R01 AG074710the Global Brain Health InstituteU.S. Department of Health and Human Services Centers for Medicare & Medicaid Services 1C1CMS331346
6 · The paper itself

Abstract

introductionCollaborative dementia care models with care navigation, including the Care Ecosystem, improve outcomes for persons living with dementia (PLWDs) and their caregivers. The effects of continuous care over long periods have not been studied.

methodsIn this randomized clinical trial with 456 PLWD-caregiver dyads with high caregiver burden, we evaluated the cumulative 5-year treatment effect on PLWD quality of life, health care utilization, caregiver depression, self-efficacy, and burden.

resultsFive-year participation was associated with higher quality of life, lower caregiver depression, and higher caregiver self-efficacy (all p's < 0.05) with a trend for lower burden (p = 0.07). Treatment effects were most robust during the first 2 years. The effects on emergency department visits and hospitalizations were not significant. DISCUSSION: The benefits of collaborative dementia care on PLWD quality of life and caregiver well-being are sustained for 5 years, and the dyads may experience the greatest benefit during the first 2 years. HIGHLIGHTS: Collaborative dementia care with care navigation was evaluated over 5 years using a randomized clinical trial. The care was associated with better quality of life for the person with dementia and well-being for the caregiver. The most robust treatment effects were in the first 2 years.

Indexed as

CaregiversDementiaQuality of LifeAgedAged, 80 and overDepressionFemaleHumansMaleMiddle AgedSelf Efficacycaregiver burdencare managementcare navigationcollaborative caredementiaquality of life

Identifiers

PMID39559905
PMCPMC11782176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.