ArticleThe journal of prevention of Alzheimer's disease2024
No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults.
Article in The journal of prevention of Alzheimer's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive impairment and dementia-Are they linked to childhood health and socioeconomic status? A systematic review.PloS one · 2025Pooled it
- Adverse childhood experiences and subsequent impact on adulthood cognitive impairment: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Association of Adverse Childhood Experiences and Cognitive Health in Older Adults: Rush Memory and Aging Project.The American journal of geriatric psychiatry. Open science, education, and practice · 2026Article
- The association between adverse experiences throughout the life-course and risk of dementia in the English Longitudinal Study of Ageing.Journal of Alzheimer's disease : JAD · 2026Article
- Childhood adversities and the exposome in dementia risk and brain health.Current opinion in psychiatry · 2026Review
- Adverse childhood experiences, early menopause, cognition, and dementia in older adults in the United States.Communications health · 2026Article
- Association of Early Life Risk Factors and APOE ε4 With Incident Dementia: Evidence From 14 Years of U.S. Data.Journal of the American Geriatrics Society · 2025Article
- Article
- Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the relationship between childhood adversity and cognitive impairment in older adults.
methodsWe analysed data from 1568 participants aged 72-79 (M = 75.1, SD = 1.5, % male = 52.6%) from Wave 4 of the Personality and Total Health (PATH) Through Life Project. The outcome variable was the presence of mild cognitive impairment (MCI) or dementia, determined through a clinically validated algorithmic diagnostic criteria. Childhood adversity was assessed using a 17-item scale covering various domestic adversities such as poverty, neglect, physical abuse, and verbal abuse. Adversity was operationalised using cumulative analysis, dichotomisation (<3 adversities; 3+ adversities), and latent class analysis. Multiple logistic regressions were employed to estimate the association between childhood adversity and cognitive impairment, while controlling for covariates including education, gender, ethnicity, and APOE ε4 status.
resultsOur analyses revealed no significant association between childhood adversity and the presence of MCI or dementia across all tested models. Sensitivity analyses, exploring alternative scenarios, consistently failed to yield statistically significant findings.
conclusionIn contrast to prevailing research findings, this study does not support a link between childhood domestic adversity and late-life cognitive outcomes. These results underscore the mixed results on adversity and cognition, highlighting the need for further research. Future investigations should consider the roles of potential mediating and protective factors within this complex relationship.
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