Evidence map›Paper›PMID 39559853›Full record

ArticleStroke2025

NSAID Allergy Labels Associated With Mortality and Cardiovascular Outcomes in Stroke.

Cheryl C W Tsui, Hugo W F Mak, William C Y Leung, Kay Cheong Teo, Yuen Kwun Wong, Valerie Chiang, Gary K K Lau, Philip H Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bridging Global Disparities in Drug Allergy Through AI-Assisted Training for Non-Specialists: Findings From the Multinational ADAPT-2 Course.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheryl C W Tsui *Division of Rheumatology and Clinical Immunology (C.C.W.T., H.W.F.M., P.H.L.), Department of Medicine, The University of Hong Kong, Pokfulam.
Hugo W F Mak *Division of Rheumatology and Clinical Immunology (C.C.W.T., H.W.F.M., P.H.L.), Department of Medicine, The University of Hong Kong, Pokfulam.ORCID 0000-0001-5085-0837
William C Y LeungDivision of Neurology (W.C.Y.L., K.C.T., Y.K.W., G.K.K.L.), Department of Medicine, The University of Hong Kong, Pokfulam.ORCID 0000-0001-7363-0239
Kay Cheong TeoDivision of Neurology (W.C.Y.L., K.C.T., Y.K.W., G.K.K.L.), Department of Medicine, The University of Hong Kong, Pokfulam.ORCID 0000-0002-3291-2958
Yuen Kwun WongDivision of Neurology (W.C.Y.L., K.C.T., Y.K.W., G.K.K.L.), Department of Medicine, The University of Hong Kong, Pokfulam.ORCID 0000-0001-6946-344X
Valerie ChiangDivision of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Pokfulam, Hong Kong (V.C.).
Gary K K LauDivision of Neurology (W.C.Y.L., K.C.T., Y.K.W., G.K.K.L.), Department of Medicine, The University of Hong Kong, Pokfulam.ORCID 0000-0002-8657-2418
Philip H LiDivision of Rheumatology and Clinical Immunology (C.C.W.T., H.W.F.M., P.H.L.), Department of Medicine, The University of Hong Kong, Pokfulam.ORCID 0000-0002-9155-9162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMislabeled drug allergy can restrict future prescriptions and medication use, but its prevalence and impact among patients with stroke remain unknown. This study investigated the prevalence of the most commonly labeled drug allergies, their accuracy, and their impact among patients with stroke.

methodsIn this combined longitudinal and cross-sectional study, we compared the prevalence of allergy labels among the general population and patients with ischemic stroke between 2008 and 2014 from electronic health care records in Hong Kong. Outcomes between patients with stroke with or without the most prevalent labels (ie, NSAID) were compared. Rate of mislabeled NSAID allergy was confirmed by provocation testing.

resultsCompared with the general population (n=702 966), patients with stroke had more labels (n=235) to cardiovascular and hematopoietic system (prevalence, 19.5% versus 9.2%; odds ratio [OR], 2.4 [95% CI, 1.74-3.32];

conclusionsNSAID allergy labels were significantly more prevalent among patients with stroke, associated with excessive mortality, peripheral vascular disease, and major adverse cardiovascular events. Given the high rate of mislabeled allergies, multidisciplinary neuro-allergy interventions could have the potential to improve patient outcomes.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalDrug HypersensitivityStrokeAgedAged, 80 and overCardiovascular DiseasesCross-Sectional StudiesDrug LabelingFemaleHong KongHumansIschemic StrokeLongitudinal StudiesMaleMiddle AgedPrevalenceAnti-Inflammatory Agents, Non-Steroidalcardiovascular diseasesHong Kongmortalityperipheral vascular diseasesstroke

Identifiers

PMID39559853
PMCPMC11812653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.