Evidence map›Paper›PMID 39559821›Full record

ArticleBiomedical reports2025

Design, synthesis, biological and

José L Madrigal-Angulo, Gustavo A Hernández-Fuentes, Hortensia Parra-Delgado, Marycruz Olvera-Valdéz, Itzia I Padilla-Martínez, Ariana Cabrera-Licona, Alexandra S Espinosa-Gil, Ivan Delgado-Enciso, Francisco J Martínez-Martínez

Abstract read
In one paragraph

Article in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. In Vitro Evaluation ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

José L Madrigal-AnguloFaculty of Chemical Sciences, University of Colima, Coquimatlán 28400, Mexico.
Gustavo A Hernández-FuentesDepartment of Molecular Medicine, School of Medicine, University of Colima, Colima 28040, Mexico.
Hortensia Parra-DelgadoFaculty of Chemical Sciences, University of Colima, Coquimatlán 28400, Mexico.
Marycruz Olvera-ValdézLaboratorio de Química Supramolecular y Nanociencias, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México 07340, Mexico.
Itzia I Padilla-MartínezLaboratorio de Química Supramolecular y Nanociencias, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México 07340, Mexico.
Ariana Cabrera-LiconaState Cancerology Institute of Colima, Health Services of The Mexican Social Security Institute for Welfare (IMSS-BIENESTAR), Colima 28085, Mexico.
Alexandra S Espinosa-GilDepartment of Molecular Medicine, School of Medicine, University of Colima, Colima 28040, Mexico.
Ivan Delgado-EncisoDepartment of Molecular Medicine, School of Medicine, University of Colima, Colima 28040, Mexico.
Francisco J Martínez-MartínezFaculty of Chemical Sciences, University of Colima, Coquimatlán 28400, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is the most common cancer and the main cause of mortality due to cancer in women around the World. Histone deacetylase 6 (HDAC6) is a promising target for the treatment of BC. In the present study, a series of novel 3-carboxy-coumarin sulfonamides, analogs of belinostat, targeting HDAC6 were designed and synthesized. The compounds were synthesized and purified through open-column chromatography. Characterization was performed using spectroscopic techniques, including

Indexed as

3-carboxy-coumarin sulfonamideshistone deacetylase inhibitorsin silico analysismolecular dockingtriple-negative breast cancer

Identifiers

PMID39559821
PMCPMC11572031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.