Evidence map›Paper›PMID 39559755›Full record

ArticleiScience2024

MOTS-c modulates skeletal muscle function by directly binding and activating CK2.

Hiroshi Kumagai, Su-Jeong Kim, Brendan Miller, Hirofumi Zempo, Kumpei Tanisawa, Toshiharu Natsume, Shin Hyung Lee, Junxiang Wan, Naphada Leelaprachakul, Michi Emma Kumagai and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Mitochondrial-derived microproteins in lung disease: insights and implications.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Hiroshi KumagaiThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Su-Jeong KimThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Brendan MillerThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Hirofumi ZempoDepartment of Administrative Nutrition, Faculty of Health and Nutrition, Tokyo Seiei College, Tokyo, Japan.
Kumpei TanisawaFaculty of Sport Sciences, Waseda University, Saitama, Japan.
Toshiharu NatsumeFaculty of Medicine, Tokai University, Kanagawa, Japan.
Shin Hyung LeeThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Junxiang WanThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Naphada LeelaprachakulThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Michi Emma KumagaiThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Ricardo RamirezThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Hemal H MehtaThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Kevin CaoThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Tae Jung OhThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
James A WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Jihui ShaDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Yuichiro NishidaDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Noriyuki FukuGraduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Shohei DobashiInstitute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
Eri Miyamoto-MikamiGraduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Mizuki TakaragawaGraduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Mizuho FukuGraduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Toshinori YoshiharaGraduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Hisashi NaitoGraduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Ryoko KawakamiPhysical Fitness Research Institute, Meiji Yasuda Life Foundation of Health and Welfare, Tokyo, Japan.
Suguru ToriiFaculty of Sport Sciences, Waseda University, Saitama, Japan.
Taishi MidorikawaCollege of Health and Welfare, J.F. Oberlin University, Tokyo, Japan.
Koichiro OkaFaculty of Sport Sciences, Waseda University, Saitama, Japan.
Megumi HaraDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Chiharu IwasakaDepartment of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Yosuke YamadaSports and Health Sciences, Graduate School of Biomedical Engineering, Tohoku University, Miyagi, Japan.
Yasuki HigakiLaboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
Keitaro TanakaDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Kelvin YenThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Pinchas CohenThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Funding

Role of the Mitochondrial Peptide Humanin in Regulating Aging and HealthspanP01AG055369 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRANDHORST, SEBASTIAN, COHEN, PINCHAS · 2018 to 2023
$12.4M
USC-Buck Institute Nathan Shock Admin CoreP30AG068345 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI LITHGOW, GORDON J · 2020 to 2024
$5.0M
Ethnic-specific Effects of Mitochondrial DNA Variants and Environmental Factors on Cognitive Functioning and DementiaR01AG068405 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS, CRIMMINS, EILEEN M · 2020 to 2024
$3.6M
Obesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · NHLBI · MAYO CLINIC ROCHESTER · PI Alfonso Eirin, Lilach O Lerman · 2022 to 2026
$3.4M
Humanin is an AD resilience factor through its interaction with APOE4RF1AG061834 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS · 2018 to 2018
$3.3M
Role of GPR120 and Macrophages in Dietary Omega-3 Fatty Acid Inhibition of Prostate CancerR01CA231219 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARONSON, WILLIAM J, COHEN, PINCHAS · 2018 to 2022
$2.1M
Metformin-Regulated Mitochondrial Peptides and their Effects on AgingR01AG069698 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS · 2020 to 2024
$2.1M
Understanding Ubiquitin-dependent Regulation of Iron Metabolism using Mass SpectrometryR35GM153408 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Akira Wohlschlegel · 2024 to 2026
$1.2M
NCI NIH HHS R01 CA231219NHLBI NIH HHS R01 HL158691NIA NIH HHS P01 AG055369NIA NIH HHS P30 AG068345NIA NIH HHS R01 AG068405NIA NIH HHS R01 AG069698NIA NIH HHS RF1 AG061834NIGMS NIH HHS R35 GM153408
6 · The paper itself

Abstract

MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of MOTS-c. MOTS-c directly binds to CK2 and activates it in cell-free systems. MOTS-c administration to mice prevented skeletal muscle atrophy and enhanced muscle glucose uptake, which were blunted by suppressing CK2 activity. Interestingly, the effects of MOTS-c are tissue-specific. Systemically administered MOTS-c binds to CK2 in fat and muscle, yet stimulates CK2 activity in muscle while suppressing it in fat by differentially modifying CK2-interacting proteins. Notably, a naturally occurring MOTS-c variant, K14Q MOTS-c, has reduced binding to CK2 and does not activate it or elicit its effects. Male K14Q MOTS-c carriers exhibited a higher risk of sarcopenia and type 2 diabetes (T2D) in an age- and physical-activity-dependent manner, whereas females had an age-specific reduced risk of T2D. Altogether, these findings provide evidence that CK2 is required for MOTS-c effects.

Indexed as

cell biologyPhysiology

Identifiers

PMID39559755
PMCPMC11570452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.