ArticleCureus2024
Effect of Indigofera aspalathoides on the Expression of Inducible Nitric Oxide Synthase During 7,12-Dimethylbenz[a]anthracene-Induced Hamster Buccal Pouch Carcinogenesis.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundThe mechanisms of inflammation and carcinogenesis are significantly influenced by nitric oxide (NO). Three different kinds of nitric oxide synthase (NOS) have been previously found: neuronal NOS, inducible nitric oxide synthase (iNOS), and endothelial NOS.
objectivesThis study looked into the properties of iNOS in hamster buccal pouch carcinogenesis caused by 7,12-dimethylbenz[a]anthracene (DMBA).
methodsThirty outbred young male Syrian golden hamsters, aged six weeks, were split into five groups at random: control (n=6), administered with ethanolic extract (n=6), DMBA+EIA (ethanolic Indigofera aspalathoides) (n=6), 0.5% solution of DMBA in liquid paraffin (n=6), and DMBA alone (n=6).
resultIn the group treated with DMBA, the mean quantity of iNOS positive foci per section was roughly 12.2+/-4.7. The DMBA-treated pouch keratinocytes showed both nuclear and cytoplasmic stainings. Neither the mineral oil-treated nor the untreated pouches (n=10) showed any signs of iNOS activity.
conclusionIn conclusion, this work has shown that hamster pouch carcinomas induced by DMBA express iNOS. This finding raises the possibility that the emergence of chemically induced oral carcinomas is linked to iNOS expression.
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