Evidence map›Paper›PMID 39559476›Full record

ArticleUrology case reports2024

Spontaneous regression of metastatic clear cell renal cell carcinoma: A report of a rare case and a review of the literature.

Anoushka Mullasseril, Anh B Lam, Alekhya Mitta, Daniel Morton, Andrew McIntosh, Sanjay Patel, Theresa Thai, Anand Annan, Adanma Ayanambakkam

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anoushka MullasserilDepartment of Internal Medicine, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Anh B LamDepartment of Internal Medicine, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Alekhya MittaDepartment of Radiation Oncology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Daniel MortonDepartment of Pediatrics, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Andrew McIntoshStephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Sanjay PatelStephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Theresa ThaiStephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Anand AnnanDepartment of Pathology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Adanma AyanambakkamStephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michael S. Businelle · 2018 to 2026
$27.1M
NCI NIH HHS P30 CA225520
6 · The paper itself

Abstract

Renal cell carcinoma (RCC) is the seventh most common cancer in the United States; clear cell RCC (ccRCC) is the most common subtype. We report a case of spontaneous regression of metastatic ccRCC and discuss possible underlying mechanisms informed by a literature review. While regression of metastatic RCC has been described following nephrectomy or treatment of the primary tumor, spontaneous regression is rare. Postulated underlying causes include tumor necrosis and immune-mediated responses. Of 29 identified cases of spontaneous regression, only ours occurred after only a biopsy. Better understanding of the pathophysiology of spontaneous regression in RCC will improve its management.

Identifiers

PMID39559476
PMCPMC11570451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.