Evidence map›Paper›PMID 39559401›Full record

ArticleJournal of inflammation research2024

Gain-of-Function Variant in Spleen Tyrosine Kinase Regulates Macrophage Migration and Functions to Promote Intestinal Inflammation.

Ye Yang, Lin Wang, Zhiyang Zeng, Chunmeng He, Yanqiu Wang, Ying Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ye Yang *Department of Gastroenterology, Children's Hospital of Fudan University/National Children's Medical Center, Shanghai, 201102, People's Republic of China.
Lin Wang *Department of Gastroenterology, Children's Hospital of Fudan University/National Children's Medical Center, Shanghai, 201102, People's Republic of China.
Zhiyang ZengDepartment of Central Laboratory, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai, 201499, People's Republic of China.
Chunmeng HeDepartment of Gastroenterology, Children's Hospital of Fudan University/National Children's Medical Center, Shanghai, 201102, People's Republic of China.
Yanqiu WangDepartment of Gastroenterology, Children's Hospital of Fudan University/National Children's Medical Center, Shanghai, 201102, People's Republic of China.
Ying HuangDepartment of Gastroenterology, Children's Hospital of Fudan University/National Children's Medical Center, Shanghai, 201102, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Spleen tyrosine kinase (Syk) is a widely-expressed cytoplasmic non-receptor tyrosine kinase involved in regulating various signaling pathways and plays an important role in chronic inflammation and autoimmune diseases. Gain-of-function Methods: Colitis was induced using dextran sodium sulfate and dinitrobenzene sulfonic acid in mice harboring a gain-of-function variant in Results: Syk Conclusion: Gain-of-function variant in

Indexed as

gain-of-function variantinflammatory bowel diseasemacrophageSYK

Identifiers

PMID39559401
PMCPMC11570706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.