ArticleInternational journal of ophthalmology2024
Causal association of obesity-related anthropometric traits with myopia and the mediating role of educational attainment: a Mendelian randomization study.
Article in International journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Obesity and Eye Diseases.Nutrients · 2026Review
- Lifestyle behaviors, serum metabolites and high myopia: Mendelian randomization and mediation analysis.International journal of ophthalmology · 2026Article
- Causal relationships between 41 inflammatory cytokines and myopia: a Mendelian randomization study.International journal of ophthalmology · 2026Article
- Critical role of lipid metabolism in axial myopia development.International journal of ophthalmology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the causal relationship between obesity-related anthropometric traits and myopia and the mediating role of educational attainment (EA).
methodsUnivariable Mendelian randomization (UVMR) was performed to evaluate the causal association between body mass index (BMI), height, waist-hip ratio (WHR, adjusted for BMI), and mean spherical equivalent (MSE). BMI was divided into fat and fat-free mass and included in multivariable Mendelian randomization (MVMR) to explore the roles of different BMI components in the causal relationship between BMI and MSE. A mediation analysis based on two-step Mendelian randomization (MR) was carried out. Specifically, UVMR was conducted to estimate the causal effect of BMI on EA. The direct effect of EA on MSE was estimated from MVMR. The mediation effect of EA in the BMI-EA-MSE model was calculated by the product of coefficients method. Expression quantitative trait loci (eQTL)-MR, reverse MR, and Linkage Disequilibrium Score Regression (LDSC) were performed to assess the robustness.
resultsGenetically predicted higher BMI had a positive total effect on MSE (
conclusionGenetically predicted higher BMI decreases the degree of myopia with a 33% mediation proportion by EA, and fat mass provides a dominant protective role in body mass-myopia. As a supplement to previous observational studies, it provides strong evidence for the relationship between anthropometric traits and refractive errors and offers a theoretical basis for future measures to prevent and control myopia.
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