ArticleHeliyon2024
Role of double-negative autoreactive cells (CD4
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Objective: Mendelian randomization (MR) was employed to explore the potential causal relationship between liposomes (LP) and rheumatoid arthritis (RA), with a focus on the mediating roles of immune cells (IC). Methods: By screening public GWAS data, LP were used as exposure data, RA as outcome data, and IC as mediating factors. The Inverse Variance Weighted (IVW) method was the main analytical technique used in this paper to evaluate causal effects. Additional techniques included the MR-Egger, weighted median, weighted mode, and simple mode methods. Cochran's Q and MR-Egger were utilized for heterogeneity and multi-effect analysis. Results: Phosphatidylcholine was revealed to enhance the risk of RA by MR analysis (P = 0.013, OR = 1.073, 95%CI = 1.015-1.136). There was no strong evidence that RA could affect liposome changes (IVW: P = 0.705, OR = 0.992, 95%CI = 0.952-1.034). The IVW method showed that increased levels of phosphatidylcholine were notably linked to higher levels of Double-Negative Autoreactive Cells (CD4 Conclusion: The present work established a causal association between LP and RA, and identified a potential mediating influence of IC. However, the specific mechanism of LP triacyl-glycerol and IC on RA is still unclear, and further research is needed.
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