ArticleIndian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India2024
Exploring Bleomycin vs. Setrol Injections in Adults.
Article in Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This retrospective study aimed to assess the efficacy of bleomycin and sodium tetradecyl sulphate (STS) as sclerotherapeutic treatment modalities for low-flow vascular and lymphatic malformations. A total of 30 patients in age group of 9-60 years with vascular and lymphatic anomalies in the head and neck region were included in our study and divided into two groups of 15 each. Patients in group 1 received bleomycin injections, while group 2 received STS for treatment. They were followed up in records for two years to look for resolution/ relapse/ recurrence of lesions. The no. of injections depended on the lesion size and response after the first and subsequent doses. Results showed that both drugs effectively treated these lesions, with no significant differences in efficacy and safety profiles. However, injection bleomycin had a slightly better cure rate (72%) than STS (61%). Both drugs required similar number of injections to be administered for a similar level of cure. Sclerotherapy provides a precious, non-invasive alternative to surgery in patients with slow-flow vascular and lymphatic anomalies. However, further research is needed to explore potential limitations and avenues for improvement.
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